Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
AssigneeAllergan, Inc.
InventorsVernon Wong, Frank Kochinke
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Abstract
Combinations of hydrophilic and hydrophobic entities in a biodegradable sustained release implant are shown to modulate each other's rate of release. Formulations of a therapeutically active agent and modulator provide substantially constant rate of release for an extended period of time.
Claims22
1-9. (canceled)
A method for treating uveitis comprising placing at least one implant in the vitreal chamber of a patient's eye afflicted with uveitis, the at least one implant comprising a matrix and an anti-inflammatory agent.
A method for treating uveitis comprising placing an extruded filament implant into the vitreal chamber of a patient's eye afflicted with uveitis, the implant comprising a PLGA copolymer and an anti-inflammatory corticosteroid, wherein the implant is configured to release the anti-inflammatory agent over a period of up to about 6 weeks.
Dependencies are inferred from the claim text.