Pharmaceutical topical gel compositions
AssigneeUnilab Pharmatech, Ltd.
InventorsDonna Valencia, Sarah Calapini, Kennie Dee
Life of this patent
Estimating the term…
Abstract
Topical alcoholic gel compositions containing dissolved pharmaceutical actives, which, in their preferred form, have excellent clarity. The alcoholic gel contains less than 20% w/w water, and uses hydroxypropylcellulose and non-neutralized, partially neutralized, or fully neutralized acrylic acid-based polymer as effective synergistic gelling system, and diols and/or triols as an optional tertiary synergistic gelling agent.
Claims20
An alcoholic gel for topical application, which comprises:
- (a). an effective amount of a pharmaceutical active ingredient other than piroxicam;
- (b). greater than 40% w/w of lower alkanol having from two to three carbon atoms;
- (c). from about 0.2% w/w to about 2% w/w of hydroxypropylcellulose;
- (d). from about 0.2% w/w to about 2% w/w of an acrylic acid-based polymer;
- and
- (e). less than 20% w/w of water.
An alcoholic gel for topical application, which comprises:
- (a). 0.02-30% w/w of a pharmaceutical active ingredient other than piroxicam;
- (b). greater than 40% w/w of ethanol;
- (c). 0.3-1.3% w/w of hydroxypropylcellulose;
- (d). 0.3-1.3% w/w of an acrylic acid-based polymer;
- (e). an amount of amine base less than or equal to about 60% of what is required to neutralize the acrylic acid-based polymer;
- and
- (f). 0-15% w/w of water.
An alcoholic gel for topical application, which comprises:
- (a). 0.02-30% w/w of a pharmaceutical active ingredient other than piroxicam;
- (b). greater than 40% w/w of ethanol;
- (c). 0.3-1% w/w of hydroxypropylcellulose;
- (d). 0.3-0.7% w/w of an acrylic acid-based polymer;
- (e). an amount of amine base to fully neutralize the acrylic acid-based polymer;
- and
- (f). 0-15% w/w of water.
An alcoholic gel for topical application, which comprises:
- (a). 10-20% w/w methyl salicylate;
- (b). 2-10% w/w menthol;
- (c). 40-80% w/w ethanol;
- (c). 10-30% w/w of a diol and/or triol;
- (d). 0.3-1.3% w/w hydroxypropylcellulose;
- (e). 0.3-1.3% w/w acrylic acid-based polymer;
- and
- (f). 0-15% w/w of water.
Dependencies are inferred from the claim text.