Signal peptides, nucleic acid molecules and methods for treatment of caries
AssigneesKane Biotech Inc., The Governing Council of the University of Toronto
InventorsDennis Cvitkovitch, Srinivasa Madhyastha
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Abstract
Peptide analogues of S. mutans CSP peptide which inhibit biofilm formation, uses thereof in the preparation of pharmaceutical compositions, antimicrobial compositions and uses thereof in the treatment and prevention of infections caused by biofilm forming bacteria, dental plaque formation, and conditions caused by dental plaque associated bacteria are provided.
Claims37
An isolated polypeptide having the amino acid sequence selected from the group consisting of SEQ ID No:
- 37, SEQ ID No:
- 39, SEQ ID No:
- 42 ,SEQ ID No:
- 44 and SEQ ID No:
- 47.
An isolated peptide analog of Streptococcus mutans competence stimulating peptide (CSP) that inhibits biofilm formation.
A composition for inhibiting or treating biofilm formation comprising a polypeptide having an amino acid sequence selected from a group consisting of:
- SEQ ID No:
- 37, SEQ ID No:
- 39, SEQ ID No:
- 42, SEQ ID No:
- 44, and SEQ ID No:
- 47, and an orally acceptable excipient.
The composition according to 12, wherein a concentration of the polypeptide is between 1 μg/ml and about 100 μg/ml.
A pharmaceutical composition comprising at least one CSP inhibitor and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.