Clostridial neurotoxins for use in wound healing
AssigneeMERZ PHARMA GmbH & CO. KGaA
InventorHarold Taylor
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Abstract
Naturally occurring and/or modified Clostridium neurotoxins, including those neurotoxins free of complexing proteins which naturally form complexes with Clostridial neurotoxins, are used to enhance healing of injured surface or superficial tissue of a patient by local administration into or in close proximity to the injured tissue. Such neurotoxins may be advantageously employed in wound healing and preventing scar formation, and find applicability in the area of ophthalmology, e.g. in treatment of injured corneal tissue, for example by closing inflamed eyes. A further embodiment includes diagnostic usage for the evaluation of effective toxin administration and medicaments for use therein.
Claims15
A method of treating a patient having a surface or superficial tissue injury, said method comprising locally administering a natural or modified Clostridium neurotoxin into or in close proximity to said injured tissue, such that healing of the injury is enhanced.
A method of determining an optimal area for injection of a Clostridium neurotoxin having long-lasting efficacy of about 12 weeks, comprising one or more initial local administrations of a natural or modified Clostridium neurotoxin having short-lasting efficacy of about 3 to 10 days in order to determine the effects of administration at a specific site or sites and thereby optimise the administration site to be used subsequently for said Clostridium neurotoxin having long-lasting efficacy.
A kit comprising separately administrable first and second components wherein the first component comprises a Clostridium neurotoxin having short-lasting efficacy of about 3 to 10 days and the second component comprises a Clostridium neurotoxin having long-lasting efficacy of about 12 weeks.
Dependencies are inferred from the claim text.