Viral vectors
OwnerJane Allen, Stephen Griffin +1inventors
InventorsJane Allen, Stephen Griffin, Andrew Michael Lever
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Abstract
A Human Immunodeficiency Virus (HIV-2) vector having a mutation within a packaging signal such that viral RNA is not packaged within an HIV-2 capsid is described. A further vector comprises an HIV-2 packaging signal and a heterologous gene capable of being expressed in the vector. These vectors may be co-transfected into a host cell to produce HIV-2 virus particles capable of expressing a heterologous gene.
Claims10
A Human Immunodeficiency Virus type 2 (HIV-2) vector comprising a mutation within an HIV-2 packaging signal such that viral RNA is not packaged within an HIV-2 capsid, wherein the mutation comprises deletion of
- (a) a sequence of SEQ ID no 1 or a variant thereof,
- (b) an internal fragment thereof of 5 or more nucleotides in length, or
- (c) a fragment thereof of 17 or more nucleotides in length.
A vector comprising an HIV-2 packaging signal sufficient to package the vector in the HIV-2 capsid and a heterologous gene capable of being expressed by the vector.
Dependencies are inferred from the claim text.