Nanotubes for cancer therapy and diagnostics
AssigneesSecretary, Department of Health and Human Services, Board of Trustees of the University of Arkansas
InventorsDan Buzatu, Jon Wilkes, Dwight Miller, Jerry Darsey, Tom Heinze, Alex Biris, Richard Beger
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Abstract
The present invention provides a novel approach to cancer therapy and diagnostics that utilizes nanotubes and other similar nanostructures as both an indirect source of radiation therapy (BNCT), and as delivery vehicles for other types of radio- and chemo-therapeutic materials, as well as imaging agents for diagnostic purposes.
Claims20
A method comprising using BN nanostructures as a source of boron in boron neutron capture therapy.
A method comprising:
- a) attaching antibody species to BN nanostructures to form BN nanostructure-antibody composite species;
- b) administering said BN nanostructure-antibody composite species to a mammalian subject such that the BN nanostructure-antibody composite species targets tumors within said subject;
- and
- c) activating at least some of the boron atoms in the BN nanostructure-antibody composite species.
A method comprising:
- a) attaching radioactive isotopes to carbon nanotubes to form radioactive-laden carbon nanotubes;
- b) attaching antibody species to said radioactive-laden carbon nanotubes to form radioactive-laden carbon nanotube-antibody species;
- and
- c) introducing said radioactive-laden carbon nanotube-antibody species into a mammal such that they can selectively target cancerous tumor cells with radiation.
A method comprising:
- a) attaching a first IgG species to BN nanotubes to form BN nanotube-IgG composite species;
- b) administering said BN nanotube-IgG composite species to a mammalian subject such that the BN nanotube-IgG composite species targets tumors within said subject;
- and
- c) activating at least some of the boron atoms in the BN nanotube-IgG composite species;
- d) attaching radioactive isotopes to carbon nanotubes to form radioactive-laden carbon nanotubes;
- e) attaching a second IgG species to said radioactive-laden carbon nanotubes to form radioactive-laden carbon nanotube-IgG species;
- and
- f) introducing said radioactive-laden carbon nanotube-IgG species into the mammal.
A composition comprising:
- a) a BN nanotube encapsulated in a bio-polymer;
- and
- b) an IgG species attached to said BN nanotube through the biopolymer.
Dependencies are inferred from the claim text.