IL-23p40 specific immunoglobulin derived proteins, compositions, epitopes, methods and uses
AssigneeCentocor, Inc.
InventorsJacqueline Benson, Mark Cunningham, Jeffrey Luo
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Abstract
An anti-IL-23 specific human Ig derived protein, isolated nucleic acids that encode at least one anti-IL-23 Ig derived protein, vectors, host cells, transgenic animals or plants, and methods of making and using thereof are useful as therapeutic and diagnostic compositions, methods and devices. The anti-IL-23 Ig derived protein preferably binds to one or more of the Seg 1, Seg 2, and Seg 3 epitopes of the p40 subunit of IL-23.
Claims37
An isolated anti-IL-23 Ig derived protein, comprising at least two CDRs, wherein said Ig derived protein specifically binds the p40 subunit of IL-23 and does not bind the p19 subunit of IL-23 or the p40 subunit of IL-12.
An isolated anti-IL-23 Ig derived protein, comprising at least two CDRs, wherein said Ig derived protein specifically binds the p40 subunit of human IL-23 at amino acids 138-145 of SEQ ID NO:1 and said Ig derived protein does not bind the p40 subunit of human IL-12.
A method of screening for or selecting an anti-IL-23 Ig derived protein, comprising using a variant human p40 subunit of IL-23, wherein the variant human p40 subunit of IL-23 is replaced by all or a portion of at least one member selected from the group consisting of Murineseg 1 of murine IL-23p40, Murineseg 2 of murine IL-23p40, and Murineseg 3 of murine IL-23p40.
A method of screening for or selecting an anti-IL-23 Ig derived protein, comprising using a variant murine p40 subunit of IL-23, wherein the variant murine p40 subunit of IL-23 is replaced by all or a portion of at least one member selected from the group consisting of Seg 1 of human IL-23p40, Seg 2 of human IL-23p40, and Seg 3 of human IL-23p40.
An isolated polypeptide comprising the human IL-23 protein of SEQ ID NO:1, wherein the amino acid sequence of Seg 2 of human IL-23p40 is replaced by the Murineseg 2 of murine IL-23p40.
An isolated polypeptide comprising the murine IL-23 protein, wherein the Murineseg 2 of murine IL-23p40 is replaced by the amino acid sequence of Seg 2 of human IL-23p40.
Any invention described herein.
Dependencies are inferred from the claim text.