Clostridial toxin derivatives and methods for treating pain
AssigneeAllergan, Inc.
InventorStephen Donovan
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Abstract
Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting moiety is selected from a group consisting of transmission compounds which can be released from neurons upon the transmission of pain signals by the neurons, and compounds substantially similar to the transmission compounds.
Claims17
A method for treating pain in a patient, the method comprising the step of administering a therapeutically effective amount of a modified Clostridial toxin to the patient;
- wherein the modified Clostridial toxin comprises a Clostridial toxin proteolytic domain;
- a Clostridial toxin translocation domain and an orphanin targeting moiety;
- and
- wherein the Clostridial toxin binding domain of the modified Clostridial toxin is removed or modified in order to reduce the targeting of the modified Clostridial toxin to the neuromuscular junction.
Dependencies are inferred from the claim text.