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US 2006/0067912 A1Published application
Methods for the induction of professional and cytokine-producing regulatory T cells
AssigneeUniversity of Southern California
InventorDavid Horwitz
Life of this patent
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Abstract
The field of the invention is generally related to methods used for the induction of T cells with suppressive activity. More specifically, the methods are used to generate professional regulatory T cells and cytokine-producing T cells with enhanced suppressive activity.
Claims12
A method for treating an undesirable or aberrant immune response in an individual comprising
- a) treating a population of CD4+ T cells comprising conventional CD25− T cells and professional CD25+ T cells with a regulatory composition comprising TGF-beta for a period sufficient to increase the number and/or suppressive activity of the regulatory/suppressor T cells obtained by said treating;
- and
- b) administering said regulatory/suppressor T cells to an individual exhibiting an undesirable or aberrant immune response.
Dependencies are inferred from the claim text.