An invertebrate animal model with neurodegenerative phenotype for screening and testing substances
OwnerDoris Kretzschmar, Jakob-Andreas Tschaepeinventors
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Abstract
The present invention claims an invertebrate animal that has been modified to express a set of genes, said set comprising the gene coding for a modified version of the gamma subunit of AMP-activated protein kinase (AMPKg). According to the invention, the animal displays an identifiable phenotype related to lipid metabolism and neurodegeneration. This animal provides a model of neurodegenerative diseases, particularly Alzheimer's disease, and may be useful for screening and testing modulating agents, substances and therapeutic compounds for neurodegenerative disorders.
Claims17
A non-human animal that expresses a modified version of the gene coding for the gamma subunit of AMP-activated protein kinase (AMPKg).
Dependencies are inferred from the claim text.