Antifungal medicaments comprising arylamidine derivatives

Use, for the manufacture of an antifungal medicament, of at least one compound of formula (I)

• in which:
• R1 is an alkyl, an alkenyl, an alkynyl, a carbocyclic or heterocyclic monovalent group, it being possible for each of these groups to be substituted, or hydrogen;
• R2 and R3, which may be identical or different, are any one of the groups defined for R1;
• a cyano;
• an acyl;
• —ORa or —SRa, with Ra corresponding to an alkyl, an alkenyl, an alkynyl, a carbocyclic or heterocyclic monovalent group, it being possible for each of these groups to be substituted, or R2 and R3, or R2 and R1 may form together and with the atoms linking them, a ring which may be substituted;
• R4 is an alkyl, an alkenyl, an alkynyl, a carbocyclic or heterocyclic monovalent group, it being possible for each of these groups to be substituted, a hydroxyl group;
• mercapto;
• azido;
• nitro;
• halo;
• cyano;
• unsubstituted or substituted acyl, amino;
• cyanato;
• thiocyanato;
• —SF5;
• —ORa;
• —SRa or —Si(Ra)3;
• m=0, 1, 2 or 3;
• the optional R5 group or the optional R5 groups, which may be mutually identical or different, have the same definition as that given above for R4;
• R6 is an unsubstituted or substituted carbocyclic or heterocyclic group;
• and
• A is a direct bond, —O—, —S(O)n—, —NR9—, —CR7═CR7—, —C≡C—, -A1-, -A1-A1, —O-(A1)k—O—, —O-(A1)k—, -A3-, -A4-, -A1O—, -A1S(O)n—, -A2-, OA2-, —NR9A2-, —OA2-A1-, —OA2-C(R7)═C(R8)—, —S(O)nA1-, -A1-A4-, -A1-A4-C(R8)═N—N═CR8—, -A1-A4-C(R8)═N—X2-X3—, -A1-A4-A3-, -A1-A4-N(R9)—, -A1-A4-X—CH2—, -A1-A4-A1-, -A1-A4-CH2X—, -A1-A4-C(R8)═N—X2-X3-X1—, -A1-X—C(R8)═N—, -A1-X—C(R8)═N—N═CR8—, -A1-X—C(R8)═N—N(R9)—, -A1-X-A—X1—, -A1-O-A3-, -A1-O—C(R7)═C(R8)—, -A1-O—N(R9)-A2-N(R9)—, -A1-O—N(R9)-A2-, -A1-N(R9)-A2-N(R9)—, -A1-N(R9)-A2-, -A1-N(R9)—N═C(R8)—, -A3-A1-, -A4-A3-, -A2-NR9—, -A1-A2-X1—, -A1-A1-A2-X1—, —O-A2-N(R9)-A2-, —CR7═CR7-A2-X1—C≡C-A2-X1—, —N═C(R8)-A2-X1—, —C(R8)═N—N═C(R8)—, —C(R8)═N—N(R9)—, —(CH2)2—O—N═C(R8)— or —X-A2-N(R9)—
• with
• n=0, 1 or 2,
• k=1 to 9,
• A1=—CHR7—,
• A2=—C(═X)—,
• A3=—C(R8)═N—O—,
• A4=—O—N═C(R8)—,
• X=O or S,
• X1=O, S, NR9 or a direct bond,
• X2=O, NR9 or a direct bond,
• X3=hydrogen, —C(═O)—, —SO2— or a direct bond,
• R7, which are mutually identical or different, each correspond to an unsubstituted or substituted alkyl, to a cycloalkyl or a phenyl, it being possible for each of these groups to be substituted, hydrogen, a halogen, a cyano, or an acyl;
• R8, which are mutually identical or different, each correspond to an alkyl, an alkenyl, an alkynyl, an alkoxy, an alkylthio, it being possible for each of these groups to be substituted, a carbocyclic or heterocyclic monovalent group which may be unsubstituted or substituted, or hydrogen;
• R9, which are mutually identical or different, each correspond to an unsubstituted or substituted alkyl, to a carbocyclic or heterocyclic monovalent group which may be unsubstituted or substituted, or to an acyl;
• or two R9 groups may form together, and with the atoms linking them, a 5-7-membered ring;
• the group represented on the right side of the bond A is linked to R6;
• or -A-R6 and R5 form together with the benzene ring M, a system of unsubstituted or substituted condensed rings;
• and the possible optic and/or geometric isomers, tautomers and salts, in particular addition salts with an acid or a base, which are pharmaceutically acceptable, of the derivatives of formula (I);
• and mixtures thereof;
• the said compound (I) being taken alone or in combination with another antifungal compound (II).