Use of ppar alpha agonists for the treatment of vascular and renal diseases
OwnerPeter Zahradka, Carla Taylorinventors
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Abstract
Activation of peroxisome proliferator activated receptor alpha (PPARα) by administration of therapeutic amounts of a PPARα agonist, WY-14643, inhibits the proliferation of vascular smooth muscle cells, hepatoma cells and human renal proximal tubule cells. WY-14643 may be applicable as a medicament for the treatment of proliferative vascular disease (atherosclerosis, hypertension), revascularization-induced injury (restenosis) and chronic renal failure.
Claims6
A pharmaceutical composition comprising a PPARα agonist;
- and a suitable excipient.
A method of treating or preventing a PPARα-related disease comprising:
- administering an effective amount of a pharmaceutical composition comprising a PPARα agonist and a suitable excipient to an individual in need of such treatment.
A kit comprising a PPARα agonist for treating or preventing a PPARα-related disorder and instructions for administration of said PPARα agonist for the treatment of an injury-related disorder.
Dependencies are inferred from the claim text.