Phenolic antiseptic compositions and methods of use

An antimicrobial composition comprising:

• an antiseptic selected from the group consisting of diphenyl ethers, phenols, halogenated phenols, bisphenols, resorcinols and its derivatives, anilides, and combinations thereof, and
• an effective amount of an enhancer selected from the group an alpha-hydroxy acid, a beta-hydroxy acid, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof, and
• a hydrophilic component,
• a surfactant other than lecithin, and
• a hydrophobic vehicle;
• wherein the composition contains at least 5 wt-% water;
• wherein the composition reduces microorganisms on human skin by one log in 6 hours when tested by the Scrub cup method on a dry skin site.

A method of treating chronic sinusitis in a subject, the method comprising contacting at least a portion of the respiratory system with an antimicrobial composition comprising:

• an antiseptic selected from the group consisting of diphenyl ethers, phenols, halogenated phenols, bisphenols, resorcinols and its derivatives, anilides, and combinations thereof;
• and
• an effective amount of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof;
• wherein the composition comprises less than 0.50 percent by weight (C6-C 18)fatty acid.

A method of treating and/or preventing an infection on the skin, mucosal tissue, and/or wound of a subject, the method comprising contacting the skin, mucosal tissue, and/or wound with an antimicrobial composition in an amount effective to kill or inactivate one or more microorganisms, wherein the antimicrobial composition comprises:

• an antiseptic selected from the group consisting of diphenyl ethers, phenols, halogenated phenols, bisphenols, resorcinols and its derivatives, anilides, and combinations thereof;
• an effective amount of an enhancer component;
• a hydrophilic component;
• and
• a hydrophobic component which forms the greatest portion of the composition by weight.

A method of treating and/or preventing an infection on the skin, mucosal tissue, and/or wound of a subject, the method comprising contacting the skin, mucosal tissue, and/or wound with an antimicrobial composition in an amount effective to kill or inactivate one or more microorganisms, wherein the antimicrobial composition comprises:

• an antiseptic selected from the group consisting of diphenyl ethers, phenols, halogenated phenols, bisphenols, resorcinols and its derivatives, anilides, and combinations thereof;
• a surfactant;
• and
• a hydrophobic component which forms the greatest portion of the composition by weight;
• wherein the antimicrobial composition contains at least 5 wt-% water.

A method of providing residual antimicrobial efficacy on the skin, mucosal tissue, and/or in a wound of a subject, the method comprising contacting the skin, mucosal tissue, and/or wound with an antimicrobial composition comprising:

• an antiseptic selected from the group consisting of diphenyl ethers, phenols, halogenated phenols, bisphenols, resorcinols and its derivatives, anilides, and combinations thereof;
• an effective amount of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof;
• a hydrophilic component;
• and
• a hydrophobic component which forms the greatest portion of the composition by weight.

A method of making an antimicrobial composition comprising an antiseptic component, an enhancer component, a hydrophobic vehicle, and a hydrophilic component, the method comprising:

• dissolving the enhancer component in the hydrophilic component;
• combining the hydrophobic vehicle and the hydrophilic component with the enhancer component dissolved therein with mixing to form a mixture;
• optionally heating the hydrophobic vehicle to a temperature sufficient to form a pourable liquid before or after combining it with the hydrophilic component and enhancer component;
• adding an antiseptic component selected from the group consisting of diphenyl ethers, phenols, halogenated phenols, bisphenols, resorcinols and its derivatives, anilides, and combinations thereof to the mixture;
• and
• cooling the mixture before or after adding the antiseptic component.

A method of making an antimicrobial composition comprising an antiseptic component, an enhancer component, and a hydrophobic vehicle, the method comprising:

• combining the enhancer component and the hydrophobic vehicle with mixing to form a mixture;
• optionally heating the hydrophobic vehicle to a temperature sufficient to make a pourable liquid before or after combining it with the enhancer component;
• adding an antiseptic component selected from the group consisting of diphenyl ethers, phenols, halogenated phenols, bisphenols, resorcinols and its derivatives, anilides, and combinations thereof to the mixture with mixing;
• and
• cooling the mixture before or after adding the antiseptic component.