Combination of an hmg-coa reductase inhibitor and a nitrate ester
OwnerGiovanni Scaramuzzinoinventor
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Abstract
The present invention relates to the therapeutical combination of an HMG-CoA reductase inhibitor (statin) and a nitrate ester and is useful mainly for the preparation of medicaments for the prevention and treatment of coronary diseases as myocardial infarction and cerebrovascular diseases as stroke. Particularly, as a nitrate ester, a nitrate prodrug of aspirin, salicylic acid or vitamin E is used. Said compositions, compared to single components, have the advantages to be without toxic effects, mainly due to statins, and to be more effective.
Claims30
a pharmaceutical composition comprising:
- a. an amount of an HMG-CoA reductase inhibitor or a pharmaceutically acceptable salt thereof
- b. an amount of nitrate ester or a pharmaceutically acceptable salt thereof
- c. pharmaceutically acceptable excipients.
A kit for achieving a therapeutic effect in in man comprising:
- a. a therapeutically effective amount of an HMG-CoA reductase inhibitor or a pharmaceutically acceptable salt thereof together with pharmaceutically acceptable excipients in a first unit dosage form
- b. a therapeutically effective amount of a nitrate ester or a pharmaceutically acceptable salt thereof together with pharmaceutically acceptable excipients in a second unit dosage form
- c. container means for containing said first and second dosage forms.
A method for treating patients in need of therapeutical treatment comprising the administration to said patients of:
- a. an amount of a first compound, said first compound being an HMG-CoA reductase inhibitor or a pharmaceutically acceptable salt thereof
- b. an amount of a second compound, said second compound being a nitrate ester or a pharmaceutically acceptable salt thereof
- wherein said first compound and said second compound are each optionally and independently administered together with pharmaceutically acceptable excipients.
Dependencies are inferred from the claim text.