Selective dopamin d3 receptor agonists for the treatment of sexual dysfunction
OwnerPieter Van der Graaf, Christopher Peter Wayman +3inventors
InventorsPieter Van der Graaf, Christopher Peter Wayman, Andrew Baxter, Andrew Cook, Stephen Wong
Life of this patent
Estimating the term…
Abstract
The use of a composition comprising a selective dopamine D3 receptor agonist, wherein said dopamine D3 receptor agonist is at least about 15-times more functionally selective for a dopamine D3 receptor as compared with a dopamine D2 receptor when measured using the same functional assay, in the preparation of a medicament for the treatment and/or prevention of sexual dysfunction.
Claims26
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A method of treating and/or preventing female sexual dysfunction (FSD), male erectile dysfunction (MED), male anorgasmia, or male hypoactive sexual desire disorder (HSDD) in a human or animal which method comprises administering to an individual an effective amount of a pharmaceutical composition comprising a selective dopamine D3 receptor agonist, wherein said dopamine D3 receptor agonist is at least about 15-times more functionally selective for a dopamine D3 receptor as compared with a dopamine D2 receptor when measured using the same functional assay;
- and wherein said agonist is optionally admixed with a pharmaceutically acceptable carrier, diluent or excipient.
An assay method for identifying an agent (hereinafter referred to as a selective dopamine D3 agonist) that can be used to treat and/or prevent female sexual dysfunction (FSD), male erectile dysfunction (MED), male anorgasmia, or male hypoactive sexual desire disorder (HSDD), the assay comprising:
- determining whether a test agent can directly enhance the endogenous genital engorgement process or erectile process;
- wherein said enhancement is defined as a potentiation of genital blood flow or intracavernosal pressure and/or cavernosal blood flow in the presence of a test agent as defined herein;
- such potentiation by a test agent is indicative that the test agent may be useful in the treatment and/or prevention of female sexual dysfunction (FSD), male erectile dysfunction (MED), male anorgasmia, or male hypoactive sexual desire disorder (HSDD), and wherein said test agent is a selective dopamine D3 receptor agonist.
A diagnostic method, the method comprising isolating a sample from a female or male;
- determining whether the sample contains an entity present in such an amount as to cause female sexual dysfunction or male sexual dysfunction;
- wherein the entity has a direct effect on the endogenous genital arousal process in the female or erectile process in the corpus cavernosum of the male;
- and wherein said entity can be modulated to achieve a beneficial effect by use of an agent;
- and wherein said agent is a selective dopamine D3 receptor agonist.
A diagnostic composition or kit comprising means for detecting an entity in an isolated female or male sample;
- wherein the means can be used to determine whether the sample contains the entity and in such an amount as to cause female sexual dysfunction (FSD), male erectile dysfunction (MED), male anorgasmia, or male hypoactive sexual desire disorder (HSDD);
- wherein the entity has a direct effect on the endogenous genital arousal process or erectile process and wherein said entity can be modulated to achieve a beneficial effect by use of an agent;
- and wherein said agent is a selective dopamine D3 receptor agonist.
An animal model used to identify agents capable of treating and/or preventing female sexual dysfunction (FSD), male erectile dysfunction (MED), male anorgasmia, or male hypoactive sexual desire disorder (HSDD), said model comprising an anaesthetised female or male animal including means to measure changes in vaginal/clitoral blood flow, intracavernosal pressure and/or cavernosal blood flow of said animal following stimulation of the pelvic nerve thereof;
- and wherein said agent in a selective dopamine D3 receptor agonist.
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.