Pharmaceutical compositions with improved dissolution
OwnerJulius Remenar, Matthew Peterson +5inventors
InventorsJulius Remenar, Matthew Peterson, Orn Almarsson, Hector Guzman, Hongming Chen, Mark Tawa, Mark Oliveira
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Abstract
The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
Claims16
1-80. (canceled)
A pharmaceutical composition comprising:
- (a) a salt form of a drug having low solubility in gastric fluid conditions;
- (b) a precipitation retardant;
- and
- (c) an optional enhancer;
- wherein the composition retards precipitation of the drug for at least 5 minutes in gastric fluid conditions.
A composition comprising a crystalline alkali metal salt of valdecoxib.
The composition of claim 4, wherein said salt is a sodium salt of valdecoxib.
A pharmaceutical composition comprising:
- (a) a salt of valdecoxib;
- (b) a sodium salt of valdecoxib;
- (c) a solvate of valdecoxib;
- or
- (d) an isopropanol solvate of valdecoxib.
The method of claim 99, wherein the composition is administered to the subject orally.
The method of claim 99, wherein the composition is used in combination with other therapies.
A composition comprising a solvate of valdecoxib.
Dependencies are inferred from the claim text.