5-Hydroxy indazole derivatives for treating glaucoma

A compound of the formula:

• wherein G is chosen from hydrogen, halogen, or C1-4alkyl;
• R is C(═O)W, or P(═O)(OX)(OY);
• R1 and R2 are hydrogen;
• R3, R4 and the carbon atom to which they are attached can form a cyclopropyl ring, or furthermore, R2 and R3 together can be (CH2)m to form a saturated heterocycle;
• when R2 and R3 are part of a heterocycle, R1,R4, independently, can be hydrogen or C1-4alkyl;
• R5 can be hydrogen or C1-4alkyl;
• W is C1-6alkyl, NR6R7, N(R6)CH2(CH2)nC(═O)N(R7)(R8), OC1-6alkyl, C1-6alkyl (which can be substituted with halogen, hydroxyl, CO2C1-4alkyl, CON(C1-4alkyl)2, C(═NH)NH2, HC(═NH)NH2, NH2), C2-4alkenyl (substituted by phenyl, unsubstituted or substituted with one or more of C1-4alkyl, C1-4alkoxy or halogen);
• R6, R7, R8 are independently chosen from hydrogen or C1-4alkyl;
• X and Y are independently chosen from hydrogen, C1-10 alkyl or X and Y can together form a lower alkyl chain of (CH2)m;
• m is 2-4;
• and
• n is 1 or 2.