Antihistamines for increased tolerance to extreme heat

Abstract

Histamine receptor antagonists are administered to delay the onset of or prevent heat stroke in mammals. H2 receptor antagonists including cimetidine, famotidine, nizatidine, and ranitidine are administered to the mammals prior to the exposure of the mammal to stress conditions, such as temperature, environmental, drug, exercise, or combinations thereof. The explosive temperature rise and precipitous mean arterial pressure crash seen in untreated subjects were delayed 2.6 fold (p<0.05) in H2 receptor antagonist-treated animals. The results teach that these antihistamines and acid reducers can increase tolerance to heat stress and may potentially increase survival to heat stress induced by environmental, drug related, or exercise and heat induced stress in athletes, military, and workers required to work in extreme temperature environments.

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