Method for modulating microbial quorum sensing
AssigneeWisconsin Alumni Research Foundation
InventorsJo Handelsman, Bradley Borlee
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Abstract
The present invention provides compositions and methods for modulating bacterial quorum sensing using antagonist or agonist compounds. Further, the present invention provides methods of treating or preventing microbial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.
Claims8
A method for modulating quorum sensing of a bacterium comprising contacting said bacterium with at least one quorum sensing compound selected from the group consisting of:
- wherein X1, X2, X3, X4, and X5 is selected from a group consisting of H, OH, F, Cl, Br, I, OR1, COOR1 and R1, wherein R1 is CnH2n-1 and n is an integer between 0-5;
- wherein X1 is O, S, N;
- X2 is O;
- Y is selected from a group consisting of a heterocyclic aromatic ring, having a nucleophilic group;
- an aromatic ring having a nucleophilic group;
- and
- wherein the nucleophilic group is selected from the group consisting of OH, F, Cl, Br, I, OR, COOR1 and R1, wherein R1 is CnH2n-1 and n is an integer between 0-5;
A pharmaceutical composition comprising
- (a) a quorum sensing compound selected from the group consisting of:
- X2, X3, X4, and X5 is selected from a group consisting of H, OH, F, Cl, Br, I, OR1, R1, wherein R1 is CnH2n-1 and n is an integer between 0-5;
- wherein X1 is O, S, N;
- X2 is O;
- Y is selected from a group consisting of a heterocyclic aromatic ring, having a nucleophilic group;
- an aromatic ring having a nucleophilic group;
- and
- wherein the nucleophilic group is selected from the group consisting of OH, F, Cl, Br, I, OR, COOR1 and R1, wherein R1 is CnH2n-1 and n is an integer between 0-5;
- (b) a pharmaceutically acceptable salt of said compound;
- and
- (c) a pharmaceutically-acceptable carrier.
A method for modulating biofilm formation on a surface, the method comprising administering to said surface a quorum sensing compound selected from the group consisting of:
- wherein X1, X2, X3, X4, and X5 is selected from a group consisting of H, OH, F, Cl, Br, I, OR1, COOR1 and R1, wherein R1 is CnH2n-1 and n is an integer between 0-5;
- wherein X1 is O, S, N;
- X2 is O;
- Y is selected from a group consisting of a heterocyclic aromatic ring, having a nucleophilic group;
- an aromatic ring having a nucleophilic group;
- and
- wherein the nucleophilic group is selected from the group consisting of OH, F, Cl, Br, I, OR, COOR1 and R1, wherein R1 is CnH2n-1 and n is an integer between 0-5;
A method of regulating microbial disease resistance or susceptibility to a microbial disease in a subject comprising the step of contacting said microbe with a quorum sensing compound selected from the group consisting of:
- wherein X1, X2, X3, X4, and X5 is selected from a group consisting of H, OH, F, Cl, Br, I, OR1, COOR1 and R1, wherein R1 is CnH2n-1 and n is an integer between 0-5;
- wherein X1 is O, S, N;
- X2 is O;
- Y is selected from a group consisting of a heterocyclic aromatic ring, having a nucleophilic group;
- an aromatic ring having a nucleophilic group;
- and
- wherein the nucleophilic group is selected from the group consisting of OH, F, Cl, Br, I, OR, COOR1 and R1, wherein R1 is CnH2n-1 and n is an integer between 0-5;
Dependencies are inferred from the claim text.