Peptide deformylase inhibitors

A compound according to Formula (1):

• wherein:
• X is selected from the group consisting of CH2, NR2, O, NR2CO, CONR2 and a bond;
• Y represents O, CH2 or a bond:
• Z represents H or F;
• R is selected from the group consisting of:
• C2-6 alkyl optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl;
• C2-6 alkenyl optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl;
• C2-6 alkynyl optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl;
• (CH2)n—C3-6 carbocycle optionally substituted by alkoxy, halogen, or C1-3 alkylsulfanyl;
• (CH2)n-R3 {where R3 is phenyl, furan, benzofuran, thiophene, benzothiophene, tetrahydrofuran, tetrahydropyran, dioxane, 1,4-benzodioxane or benzo[1,3]dioxole;
• R3 is optionally substituted by one or more Cl, Br, I, C1-3 alkyl optionally substituted by one to three F, or C1-2 alkoxy, optionally substituted by one to three F};
• R1 is selected from the group consisting of:
• hydrogen, C1-3 substituted alkyl, C2-3 substituted alkenyl, C2-3 substituted alkynyl, (CH2)n—C3-6 substituted carbocycle, aryl, heteroaryl, heterocyclic, and aminocarbonyl provided that X is (CH2)n when R1 represents aminocarbonyl;
• R2 represents:
• hydrogen, or C1-3 substituted alkyl;
• X represents (CH2)n, NR2, O, NR2CO, CONR2 or a bond;
• Y represents O, CH2 or a covalent bond;
• Z represents hydrogen or fluorine;
• preferably fluroine;
• and n represents an interger between 0 and 2 or a salt, solvate, or physiologically functional derivative thereof.