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US 2006/0052421 A1Published application
Conjugation agent
AssigneeEastman Kodak Company
InventorsThomas Welter, Kevin Dockery
Life of this patent
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Abstract
Conjugation agents of the formula: are described, wherein Sx is —S—, —SO— or —SO2—; Rs is a carbon-containing substituent that does not include a cyano group; each R is a substituent, with at least one R having a reaction site that is not a carboxylic acid; n is 0-5; each A is carbon or nitrogen, with the proviso that no more than three A can be nitrogen; and Sx—Rs is a leaving group. The conjugation agents have good thiol reactivity and selectivity, and good stability with regard to hydrolysis.
Claims26
A conjugation agent of the formula:
- wherein Sx is —S—, —SO— or —SO2—;
- Rs is a carbon-containing substituent that does not include a cyano group;
- each R is a substituent, with at least one R having a reaction site that is not a carboxylic acid;
- n is 0-5;
- each A is carbon or nitrogen, with the proviso that no more than three A can be nitrogen;
- and wherein Sx—Rs is a leaving group.
3 more elements
Dependencies are inferred from the claim text.