2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof

At least one chemical entity chosen from compounds of Formula I:

• and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof, wherein
• R3 is chosen from hydroxy, alkoxy, amino, substituted amino, and Ar;
• Ar is chosen from cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
• L is chosen from C0-C4alkylene, substituted C1-C4alkylene, —(C0-C4alkylene)-NH—(C═O)—;
• and —(C0-C4alkylene)(C═O)—;
• W is chosen from hydrogen, halo, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
• Q is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
• and
• Z is chosen from alkyl, and substituted alkyl,
• with the provisos that
• when Q is optionally substituted pyridin-3-yl, L is a covalent bond, W is 3-methylphenyl, R3 is optionally substituted pyridin-4-yl, then Z is not methyl;
• when Ar is pyridin-4-yl, W is hydrogen, and Q is chosen from benzyl, substituted benzyl, phenethyl, and substituted phenethyl, then Z is not chosen from lower alkyl and substituted lower alkyl;
• when Ar is 2-oxo-(3-hydroquinolyl), W is hydrogen, Z is methyl, then Q is not phenyl;
• when W is chosen from 2-(cyclohexylamino)pyridin-4-yl and 2-(cyclopentylamino)pyridin-4-yl, Ar is 3-methylphenyl, Z is methyl, then Q is not pyridin-3-yl or 6-methylpyridin-3-yl;
• Ar is not substituted pyridone or benzoyloxypyridine;
• when either R1 or R2 is hydrogen, then Ar is not 4-pivaloyloxyphenyl;
• Q is not a heteroaryl, substituted heteroaryl, heterocycloalkyl or substituted heterocycloalkyl comprising one or more heteroatoms chosen from S and N, fused with an aryl, substituted aryl, heteroaryl, or substituted heteroaryl ring;
• when Z is lower alkyl or 3-morpholinopropyl, then Ar is not phenyl, 4-methoxyphenyl, or 2,5-dimethoxyphenyl;
• when Ar is pyridinyl, L is a covalent bond, Z is hydrogen or methyl, and W is phenyl substituted with one methoxy, methyl, chloro, fluoro, chloroor t-butyl, then Q is not methyl;
• and
• when Ar is 4-t-butylphenyl, L is a covalent bond, Z is propyl and Q is 1-cyano-2-hydroxy-prop-1-enyl, then W is not hydrogen.