Back to results
US 2006/0052412 A1Published application
2-Substituted-1-deaza purine derivatives with adenosine receptor modulating activity
AssigneeSolvay Pharmaceuticals GmbH
InventorsMelle Koch, Jacobus Hartog, Martinus Wanner, Gerrit-Jan Koomen
Life of this patent
Estimating the term…
Abstract
The present invention relates to 2-substituted-1-deaza purine derivatives as adenosine receptor modulating agents, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said purine derivatives. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.
Claims7
Compounds of the general formula (1):
- wherein:
- R1 represents oxa-3-azabicyclo[2.2.2]oct-5-en-3-yl, 4-hydroxy-cyclohexyl-NH—, optionally substituted arylalkyl(C1-3)amines, cycloalkyl(C3-8)alkyl-(C1-3)amines, arylalkyl(C1-3)hydrazines or cycloalkyl(C1-3)alkyl-(C1-3)hydrazines
- R2 represents amino, NH-alkyl(C1-3) or N-dialkyl(C1-3) optionally substituted arylalkyl(C1-3)amines or cycloalkyl(C3-8)alkyl-(C1-3)amines,
- R3 represents hydrogen, alkyl(C1-3) or arylalkyl(C1-3) and tautomers, stereoisomers, prodrugs and salts thereof,
1 more element
Dependencies are inferred from the claim text.