Pharmaceutical composition for treating pain comprising oxicarbazepine, or derivatives thereof, and cox2 inhibitors
OwnerMargaret Hopwood, Donald Manninginventors
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Abstract
A pharmaceutical composition for treatment of pain, comprises in combination oxcarbazepine or derivative thereof as defined and a COX-2 inhibitor for simultaneous, sequential or separate use. Also provided is a method of treating a patient suffering from pain, comprising administering to the patient an effective amount of oxcarbazepine or derivative thereof and an effective amount of a COX-2 inhibitor.
Claims16
A pharmaceutical composition for treatment of pain, which comprises in combination oxcarbazepine or derivative thereof of formula I
- wherein X is ═O or —OH, the bond between the azepine ring and X being a double bond when X is ═O and a single bond when X is —OH, and a COX-2 inhibitor for simultaneous, sequential or separate use.
(canceled)
(canceled)
A method of treating a patient suffering from pain comprising administering to the patient an effective amount of oxcarbazepine or derivative thereof of formula I,
- wherein X is ═O or —OH, the bond between the azepine ring and X being a double bond when X is ═O and a single bond when X is —OH, and an effective amount of a COX-2 inhibitor.
A package comprising oxcarbazepine or derivative thereof of formula I
- wherein X is ═O or —OH, the bond between the azepine ring and X being a double bond when X is ═O and a single bond when X is —OH, for treatment of pain according to a method wherein said oxcarbazepine or derivative thereof of formula I is used in combination with a COX-2 inhibitor or a package comprising a COX-2 inhibitor for treatment of pain according to a method wherein said COX-2 inhibitor is used together with instructions for use in combination with oxcarbazepine or derivative thereof of formula I as defined above.
A pharmaceutical composition for treatment of pain, which comprises in combination oxcarbazepine or derivative thereof of formula II
- wherein X′ is ═O, —OH or H, the bond between the azepine ring and X′ being a double bond when X′ is ═O and a single bond when X′ is —OH or H and the bond (a) of the azepine ring being a single bond when X′ is ═O or —OH and a double bond when X′ is H, and a COX-2 inhibitor of formula VI
- wherein R′ is methyl or ethyl;
- R1′ is chloro or fluoro;
- R2′ is hydrogen or fluoro;
- R3′ is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy;
- R4′ is hydrogen or fluoro;
- and
- R5′ is chloro, fluoro, trifluoromethyl or methyl;
- for simultaneous, sequential or separate use.
(canceled)
(canceled)
A method of treating a patient suffering from pain comprising administering to the patient an effective amount of oxcarbazepine or derivative thereof of formula II,
- wherein X′ is ═O, —OH or H, the bond between the azepine ring and X′ being a double bond when X′ is ═O and a single bond when X′ is —OH or H and the bond (a) of the azepine ring being a single bond when X′ is ═O or —OH and a double bond when X′ is H, and an effective amount of a COX-2 inhibitor of formula VI
- wherein R′ is methyl or ethyl;
- R1′ is chloro or fluoro;
- R2′ is hydrogen or fluoro;
- R3′ is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy;
- R4′ is hydrogen or fluoro;
- and
- R5′ is chloro, fluoro, trifluoromethyl or methyl.
A package comprising oxcarbazepine or derivative thereof of formula II
- wherein X′ is ═O, —OH or H, the bond between the azepine ring and X′ being a double bond when X′ is ═O and a single bond when X′ is —OH or H and the bond (a) of the azepine ring being a single bond when X′ is ═O or —OH and a double bond when X′ is H, for treatment of pain according to a method wherein said oxcarbazepine or derivative thereof of formula II is used in combination with a COX-2 inhibitor of formula VI
- wherein R′ is methyl or ethyl;
- R1′ is chloro or fluoro;
- R2′ is hydrogen or fluoro;
- R3′ is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy;
- R4′ is hydrogen or fluoro;
- and
- R5′ is chloro, fluoro, trifluoromethyl or methyl, or a package comprising a COX-2 inhibitor of formula VI as defined above for treatment of pain according to a method wherein said COX-2 inhibitor is used in combination with oxcarbazepine or derivative thereof of formula II as defined above.
Dependencies are inferred from the claim text.