Quinazolinone compounds as calcilytics

A compound having the chemical formula:

• wherein:
• R1, R2 and R3 is each independently selected from one of:
• H, halogen, CN, CF3, OCF3, lower alkyl, lower alkoxy, NH-acetyl, NH-lower alky, NH-alkylaryl;
• N(lower alkyl)2, C(O)OH, C(O)O-lower alkyl, C(O)NH-lower alkyl, C(O)N(lower alkyl)2, OH, OC(O)-lower alkyl, OC(O)-lower alkyalamino, OC(O)-lower alkyl-N(lower alkyl)2, and OP(O)(OH)2;
• R4 is optional and may be selected from one of:
• H, halogen, CN, CF3, OCF3, lower alkyl, lower alkoxy, NH-acetyl, NH-lower alky, NH-alkylaryl, N(lower alkyl)2, C(O)OH, C(O)O-lower alkyl, C(O)NH-lower alkyl, C(O)N(lower alkyl)2, OH, OC(O)-lower alkyl, OC(O)-lower alkyalamino, OC(O)-lower alkyl-N(lower alkyl)2, and OP(O)(OH)2;
• X1 is selected from one of C and N,
• R5 is selected from one of:
• H lower alkyl, a furyl, thienyl, styryl, pyridyl and phenyl group optionally substituted with 1 to 3 substituents selected from one of H, halogen, CN, CF3, OCF3, lower alkyl, NH-alkylaryl, N(lower alkyl)2, lower alkoxy, OH, OC(O)-lower alkyl, OC(O)-lower alkyalamino, OC(O)-lower alkyl-N(lower alkyl)2, and OP(O)(OH)2;
• R6 is selected from one of:
• H, lower alkyl, and a group comprising —(CH2)n—X2—R7 wherein n is 0, 1, or 2, X2 is O, C(O), CH(OH), lower alkyl or a single bond, and
• R7 is an aromatic group optionally substituted with 1 to 3 substituents selected from one of:
• H, halogen, CN, CF3, OCF3, lower alkyl, lower alkoxy, NH-lower alkyl, NH-alkylaryl, N(lower alkyl)2, OH, OC(O)-lower alkyl, OC(O)-lower alkyalamino, OC(O)-lower alkyl-N(lower alkyl)2, and OP(O)(OH)2;
• or a pharmaceutically acceptable salt or complex thereof.