Bone growth factor
OwnerCherk Taminventor
Life of this patent
Estimating the term…
Abstract
A compound having bone stimulatory activity: in which: X1 and X10 are positively charged polar amino acids; X4 and X8 are negatively charged polar amino acids; X5 is an aromatic amino acid; X2, X3, X6 and X7 are non polar neutral amino acids or uncharged polar amino acids; Z represents a blocking group; and n is an integer from 1 to 3.
Claims21
A compound having bone stimulatory activity, the compound comprising a peptide having an amino acid sequence of Formula I:
- in which:
- X1 and X10 are positively charged polar amino acids;
- X4 and X8 are negatively charged polar amino acids;
- X5 is an aromatic amino acid;
- X2, X3, X6 and X7 are non polar neutral amino acids or uncharged polar amino acids;
- Z represents a blocking group;
- and n is an integer from 1 to 3.
A peptide with bone stimulatory activity comprising an amino acid sequence containing 10-amino acids selected from the group consisting of peptides of the following Formula Ia:
- K T Q E F T A E X9 K
- R T Q E F T A E X9 K
- R T Q E H T A E X9 K
- K T Q E H T A E X9 K Formula Ia
- in which X9 is methionine or a modified methionine or a modified cysteine.
A peptide having the amino acid sequence identified as SEQ ID NO:1, wherein the N-terminus is optionally protected with an acetyl group, and the C-terminus optionally protected with an amino group.
A peptide having the amino acid sequence identified as SEQ ID NO:2, wherein the N-terminus is optionally protected with an acetyl group, and the C-terminus optionally protected with an amino group.
A peptide having the amino acid sequence identified as SEQ ID NO:3, wherein the N-terminus is optionally protected with an acetyl group, and the C-terminus optionally protected with an amino group.
A peptide having the amino acid sequence identified as SEQ ID NO:4, wherein the N-terminus is optionally protected with an acetyl group, and the C-terminus optionally protected with an amino group.
A peptide having the amino acid sequence identified as SEQ ID NO:5, wherein the N-terminus is optionally protected with an acetyl group, and the C-terminus optionally protected with an amino group.
A peptide having the amino acid sequence identified as SEQ ID NO:6, wherein the N-terminus is optionally protected with an acetyl group, and the C-terminus optionally protected with an amino group.
20-22. (canceled)
Dependencies are inferred from the claim text.