Method of treating osteoporosis using intranasal parathyroid hormone
AssigneeNastech Pharmaceutical Company Inc.
InventorsSteven Quay, Gordon Brandt, Henry Costantino
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Abstract
What is described is a method for treating osteoporosis in a mammal comprising administering intranasally a therapeutically effective amount of a PTH formulation to the mammal wherein the PTH formulation is an aqueous formulation comprised of a PTH peptide and one or more excipients selected from the group consisting of a water-miscible polar organic solvent, a surface active agent, and a chelating agent for cations.
Claims22
A method for treating osteoporosis in a mammal comprising administering intranasally a therapeutically effective amount of a PTH formulation to the mammal wherein the PTH formulation is an aqueous formulation comprising a PTH peptide and one or more excipients selected from the group consisting of a water-miscible polar organic solvent, a surface active agent, and a chelating agent for cations.
A method for treating osteoporosis in a mammal comprising administering intranasally a therapeutically effective amount of a PTH formulation to the mammal, wherein the PTH formulation is comprised of a PTH peptide and one or more expcipients selected from the group consisting of a solubilizing agent, a chelating agent, and one or more polyols.
A method for treating osteoporosis in a mammal comprising administering intranasally a therapeutically effective amount of a PTH formulation to the mammal, wherein a time to maximum plasma concentration, Tmax, of said peptide following administration of said formulation to the mammal is less than 30 minutes.
Dependencies are inferred from the claim text.