Mntf peptides and compositions and methods of use
AssigneeGenervon Biopharmaceuticals LLC
InventorsRaymond Chau, Pui-Yuk Ko
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Abstract
The present invention is directed to novel peptides and compositions capable of modulating viability and growth in neuronal cells, and to methods of modulating neuronal cell viability and growth employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to novel peptide analogues of motoneuronotrophic factor 1 containing either a “WMLSAFS” or “FSRYAR domain,” which is sufficient for neurotrophic or neurotropic function.
Claims24
A motoneuronotrophic factor peptide analogue 6 to 32 amino acids in length, said peptide analogue containing an amino acid sequence selected from the group consisting of:
- (a) SEQ ID NO:2;
- and
- (b) SEQ ID NO:3
- wherein said peptide analogue enhances the viability of motor neurons.
A conjugate comprising:
- (a) a motoneuronotrophic factor peptide 6 to 32 amino acids in length containing an amino acid sequence selected from the group consisting of SEQ ID NO:
- 2 and SEQ ID NO:3;
- and
- (b) a solid particle, carrier protein or label linked to the motoneuronotrophic factor peptide.
A fusion protein comprising:
- (a) a motoneuronotrophic factor peptide 6 to 32 amino acids in length containing an amino acid sequence selected from the group consisting of SEQ ID NO:
- 2 and SEQ ID NO:3;
- and
- (b) a heterologous protein fused to the motoneuronotrophic factor peptide.
Dependencies are inferred from the claim text.