Use of stable glutamine derivatives to improve drug absorption
OwnerRichard Guerrant, Nathan Thielman +2inventors
InventorsRichard Guerrant, Nathan Thielman, Gerly de Castro Brito, Aldo Lima
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Abstract
The present invention relates to compositions and their use to enhance the uptake of pharmaceutical agents administered to mammalian species, including humans. More particularly, the present invention is directed to the administration of glutamine and stabilized glutamine derivatives to enhance the uptake of orally administered therapeutic agents.
Claims30
A method of enhancing the absorption of a pharmaceutical agent administered orally to a mammal, said method comprising the steps of
- administering to said mammal a composition comprising a glutamine-bearing compound;
- and
- administering orally to said mammal the pharmaceutical agent.
A composition for enhancing the uptake of a pharmaceutical agent by a mammal, wherein the mammal is suffering from intestinal mucosa damage, said composition comprising a glutamine-bearing compound, or pharmaceutically-acceptable salt thereof, and a pharmaceutical agent.
A method of reducing the emergence of antiretroviral drug resistance in a chronic wasting patient receiving orally administered antiretroviral therapy, said method comprising the steps of
- administering to said patient a composition comprising a glutamine-bearing compound;
- and
- administering to said patient an antiretroviral drug.
Dependencies are inferred from the claim text.