Chemically-modified progenipoietin conjugates
OwnerNed Siegal, Rory Finn +1inventors
InventorsNed Siegal, Rory Finn, Robert Hills
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Abstract
The present invention provides a chemically modified Progenipoietins (ProGPs) prepared by binding a water soluble polymer to the protein. The chemically-modified protein according to the present invention may have a much longer lasting neutrophil-increasing activity than that of the un-modified ProGP, enabling reduced dose and scheduling opportunities.
Claims26
A Progenipoietin conjugate having at least one water-soluble polymer molecule covalently attached to at least one amino acid residue of a biologically active Progenipoietin polypeptide.
A method of conjugating a poly(ethylene glycol) to a nucleophile wherein the conjugation is carried out in the presence of an inorganic solvent.
Dependencies are inferred from the claim text.