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US 2006/0052289 A1Published application
Use of somatostatin analogs in sleep apnea
OwnerChristian Bruns, Peter Marbachinventors
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Abstract
Somatostatin analogues, e.g. comprising an amino acid sequence of formula -(D/L)Trp-Lys-X1-X2- wherein each of X1, and X2 is an amino acid residue as disclosed in the specification, have interesting properties in the treatment of sleep apnea.
Claims7
1-4. (canceled)
A method for the treatment of sleep apnea in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a somatostatin analogue selected from KE108 and a somatostatin analogue of formula I
- -(D/L)Trp-Lys-X1-X2- I
- wherein X1 is a radical of formula (a) or (b)
- wherein R1 is optionally substituted phenyl, wherein the substituent may be halogen, methyl, ethyl, methoxy or ethoxy,
- wherein Z1 is O or S, and
- X2 is an α-amino acid having an aromatic residue on the Cα side chain, or an amino acid unit selected from Dab, Dpr, Dpm, His, (Bzl)HyPro, thienyl-Ala, cyclohexyl-Ala and t-butyl-Ala, the residue Lys of said sequence corresponding to the residue Lys9 of the native somatostatin-14, or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.