US 2006/0052285 A1 · Mechanism of mitochondrial membrane permeabilization by HIV-1 VPR, mimetics of Vpr and methods of screening active molecules having the ability to alter and/or prevent and/or mimic the interaction of Vpr with ANT

Mechanism of mitochondrial membrane permeabilization by HIV-1 VPR, mimetics of Vpr and methods of screening active molecules having the ability to alter and/or prevent and/or mimic the interaction of Vpr with ANT

AssigneesInstitut Pasteur, Institut National de la Sante et de la Recherche Medicale, Centre National De La Recherche Scientifique, Universite De Technologie De Compiegne

InventorsEtienne Jacotot, Guido Kroemer, Bernard Roques, Lena Edelman, Johan Hoebeke, Catherine Brenner-Jean, Anne-Sophie Belzacq

Life of this patent

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Abstract

The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleotide translocase or ADP/ATP carrier). Reagents and methods for inducing and/or inhibiting the binding of Vpr to ANT, mitochondrial membrane permeabilization, and apoptosis are provided.

Claims2

Dependent claims

A method of preventing interaction of Vpr with ANT comprising:

(a) providing a molecule capable of preventing the binding of full-length Vpr to ANT;
and
(b) contacting said molecule with an ANT fragment;
wherein said molecule prevents the interaction of said ANT fragment with Vpr.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

11/176,370Filed 8 Jul 2005

Priority

11 Sep 2000

Published

9 Mar 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification18 codes

C07K 14/005
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from viruses
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
C07K 14/47
From vertebrates: from mammals
C07K 14/4747
Not used: apoptosis related proteins

Family

Application60/231,539Us provisional application · filed 11 Sep 2000

Application60/232,841Us provisional application · filed 15 Sep 2000

Application09/949,650Continuation · filed 12 Sep 2001

Application11/176,370Continuation · filed 8 Jul 2005

US 2002/0068273 A1Published application

US 7,056,735 B2Related patent

US 7,642,051 B2Related patent

US 2006/0052285 A1This patent

From the US filing history. Foreign family members aren’t listed.