Back to results
US 2006/0052270 A1Published application
Solid dispersion compositions
AssigneeSmithKline Beecham Corporation
InventorsKamlesh Patel, Raviraj Pillai
Life of this patent
Estimating the term…
Abstract
Disclosed is a water-dispersible solid composition of a sparingly water-soluble compound in a particulatable lipidic carrier, methods for the preparation and use of the same. The compositions of this intention provide improved solubility and dissolution characteristics and enhanced bioavailability of the sparingly soluble compound.
Claims19
A water-dispersible particulate composition having an overall melting point of 40° C. or higher comprising a solid molecular dispersion comprised of:
- about 0.01% to about 15% by weight of a sparingly water-soluble compound and about 85-99.99% by weight of a particulatable lipidic carrier,
- wherein the particulatable lipidic carrier is comprised of:
- about 5% to about 50% by weight of a lipid-based surfactant selected from the group consisting of a polyglycolized glyceride, a polyoxyethylene castor oil derivative, a polyoxyethylene stearate having a melting point of from 40° C. to 50° C., and a mixture thereof, and
- about 50% to about 95% by weight of a stiffening agent having a melting point of from 50° C. to 80° C. and selected from the group consisting of glycerol monostearate, glycerol palmitostearate, hydrogenated vegetable oil, and a mixture thereof.
1 more element
Dependencies are inferred from the claim text.