Antiseptic compositions and methods of use
Assignee3M Innovative Properties Company
InventorsMatthew Scholz, Terry Hobbs
Life of this patent
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Abstract
Antimicrobial compositions, especially those useful when applied topically to tissue, such as mucosal tissues (i.e., mucous membranes), that include an antimicrobial selected from the group consisting of peroxides, C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and antimicrobial natural oils. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and/or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and/or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).
Claims101
A method of killing or inactivating microorganisms on mammalian tissue, the method comprising contacting the affected area with an antimicrobial composition in an amount effective to kill or inactivate one or more microorganisms, the antimicrobial composition comprising:
- a peroxide antiseptic;
- a hydrophobic component, and
- a hydrophilic component other than water.
An antimicrobial composition comprising:
- an peroxide antiseptic, and
- an effective amount of an enhancer selected from the group an alpha-hydroxy acid, a beta-hydroxy acid, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof, and
- a hydrophilic component,
- a surfactant, and
- a hydrophobic vehicle;
- wherein the antimicrobial composition contains less than 5 wt-% water and
- wherein the composition reduces microorganisms on human skin by two log in ten minutes when tested by the Scrub cup method.
A method of killing or inactivating microorganisms on mammalian skin, the method comprising contacting the affected area with an antimicrobial composition in an amount effective to kill or inactivate one or more microorganisms, the antimicrobial composition comprising:
- an antiseptic selected from the group consisting of C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils;
- an effective amount of an enhancer component;
- a hydrophilic component;
- and
- a hydrophobic component which forms the greatest portion of the composition.
A method of killing or inactivating microorganisms on mammalian tissue, and/or in a wound of a subject, the method comprising contacting the affected area with an antimicrobial composition in an amount effective to kill or inactivate one or more microorganisms, the antimicrobial composition comprising:
- an antiseptic selected from the group consisting of C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils;
- and
- an effective amount of an enhancer component.
A method of killing or inactivating microorganisms on mammalian skin, the method comprising contacting the affected area with an antimicrobial composition in an amount effective to kill or inactivate one or more microorganisms, the method comprising:
- an antiseptic selected from the group consisting of C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils;
- and
- a hydrophobic component which forms the greatest portion of the composition by weight.
A method of decolonizing at least a portion of the nasal cavities, anterior nares, and/or nasopharynx of a subject, the method comprising contacting the nasal cavities, anterior nares, and/or nasopharynx with an antimicrobial composition comprising an antiseptic selected from the group consisting of C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils;
- and
- a hydrophobic vehicle, and
- a hydrophilic component or a surfactant.
An antimicrobial composition comprising:
- an antiseptic selected from the group consisting of C6-C14 alkyl carboxylic acids and C6-C14 alkyl carboxylate ester carboxylic acids, and C8-C22 mono- or polyunsaturated carboxylic acids;
- an effective amount of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof;
- a surfactant;
- and
- a hydrophilic vehicle;
- wherein the viscosity of the composition is at least 500 cps.
An antimicrobial composition comprising:
- an antiseptic selected from the group consisting of C6-C14 alkyl carboxylic acids and C6-C14 alkyl carboxylate ester carboxylic acids present in a concentration of at least 0.2 percent;
- an effective amount of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof, and
- a hydrophobic vehicle.
An antimicrobial composition, comprising
- an natural oil antiseptic, and
- a hydrophobic vehicle,
- wherein the composition reduces microorganisms on human skin by one log in 6 hours when tested by the Scrub cup method on a dry skin site.
A method of decolonizing at least a portion of the esophageal cavity of a subject, the method comprising contacting the esophageal cavity with an antimicrobial composition comprising
- an antiseptic selected from the group consisting of peroxides, C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and antimicrobial natural oils,
- a hydrophobic vehicle, and
- a hydrophilic component.
An antimicrobial composition, comprising
- an antiseptic selected from the group consisting of peroxides, C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, antimicrobial natural oils,
- a hydrophilic component, and
- a hydrophobic component,
- wherein the composition contains less than 5 wt-% water, and
- wherein the composition reduces microorganisms on human skin by one log in 6 hours when tested by the Scrub cup method on a dry skin site.
A method of treating a middle ear infection in a subject, the method comprising contacting the middle ear, tympanic membrane, and/or Eustachian tube with an antimicrobial composition comprising:
- an antiseptic selected from the group consisting of peroxides, C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils;
- and
- an effective amount of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof.
A method of treating a middle ear infection in a subject, the method comprising contacting the middle ear, tympanic membrane, and/or Eustachian tube with an antimicrobial composition comprising:
- an antiseptic selected from the group consisting of peroxides, C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils;
- and
- a hydrophobic component which forms the greatest portion of the composition by weight.
A method of treating chronic sinusitis in a subject, the method comprising contacting at least a portion of the respiratory system with an antimicrobial composition comprising:
- an antiseptic selected from the group consisting of peroxides and natural oils;
- and
- an effective amount of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof;
- wherein the composition comprises less than 0.50 percent by weight (C6-C18)fatty acid.
A method of treating chronic sinusitis in a subject, the method comprising contacting at least a portion of the respiratory system with an antimicrobial composition comprising:
- an antiseptic selected from the group consisting of peroxides, C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils;
- and
- a hydrophobic component which forms the greatest portion of the composition by weight.
A method of treating impetigo on the skin of a subject, the method comprising contacting the affected area with an antimicrobial composition comprising:
- an antiseptic selected from the group consisting of peroxides, C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils;
- and
- an effective amount of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof.
A method of treating impetigo on the skin of a subject, the method comprising contacting the affected area with an antimicrobial composition comprising:
- an antiseptic selected from the group consisting of peroxides, C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils;
- and
- a hydrophobic component which forms the greatest portion of the composition by weight.
A method of treating and/or preventing an infection on mammalian skin, the method comprising contacting the tissue with an antimicrobial composition in an amount effective to kill or inactivate one or more microorganisms, wherein the antimicrobial composition comprises:
- an antiseptic selected from the group consisting of peroxides, C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils;
- an effective amount of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof;
- a hydrophilic component;
- and
- a hydrophobic component which forms the greatest portion of the composition by weight.
A method of treating and/or preventing an infection on mammalian tissue, and/or wound of a subject, the method comprising contacting the mammalian tissue, and/or wound with an antimicrobial composition in an amount effective to kill or inactivate one or more microorganisms, wherein the antimicrobial composition comprises:
- an antiseptic selected from the group consisting of peroxides, C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils;
- an effective amount of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof;
- a surfactant;
- and
- a hydrophobic component which forms the greatest portion of the composition by weight;
- wherein the antimicrobial composition contains less than 5 wt-% water.
A method of providing residual antimicrobial efficacy on the skin, mucosal tissue, and/or in a wound of a subject, the method comprising contacting the skin, mucosal tissue, and/or wound with an antimicrobial composition comprising:
- an antiseptic selected from the group consisting of peroxides, C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils;
- an effective amount of an enhancer component comprising an alpha-hydroxy acid, a beta-hydroxy acid, a chelating agent, a (C1-C4)alkyl carboxylic acid, a (C6-C12)aryl carboxylic acid, a (C6-C12)aralkyl carboxylic acid, a (C6-C12)alkaryl carboxylic acid, a phenolic compound, a (C1-C10)alkyl alcohol, an ether glycol, or combinations thereof;
- a hydrophilic component;
- and
- a hydrophobic component which forms the greatest portion of the composition by weight.
A method of making an antimicrobial composition comprising an antiseptic component, an enhancer component, a hydrophobic vehicle, and a hydrophilic component, the method comprising:
- dissolving the enhancer component in the hydrophilic component;
- combining the hydrophobic vehicle and the hydrophilic component with the enhancer component dissolved therein with mixing to form a mixture;
- optionally heating the hydrophobic vehicle to a temperature sufficient to form a pourable liquid before or after combinint it with the hydrophilic component and enhancer component;
- adding the antiseptic component selected from the group consisting of peroxides, C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils to the mixture;
- and
- cooling the mixture before or after adding the antiseptic component.
A method of making an antimicrobial composition comprising an antiseptic component, an enhancer component, and a hydrophobic vehicle, the method comprising:
- combining the enhancer component and the hydrophobic vehicle with mixing to form a mixture;
- optionally heating the hydrophobic vehicle to a temperature sufficient to make a pourable liquid before or after combining it with the enhancer component;
- adding the antiseptic component selected from the group consisting of peroxides, C6-C14 alkyl carboxylic acids, C6-C14 alkyl carboxylate ester carboxylic acids, C8-C22 mono- or polyunsaturated carboxylic acids, and natural oils to the mixture with mixing;
- and
- cooling the mixture before or after adding the antiseptic component.
Dependencies are inferred from the claim text.