Abuse resistent pharmaceutical dosage and method of making same
OwnerPieter Groenewoudinventor
Life of this patent
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Abstract
A pharmaceutical composition includes a therapeutic amount of an active ingredient and at least one gel-forming granule. The gel-forming granule forms a gel when exposed to an aqueous liquid and is coated with an outer coating that is sufficiently brittle so that when the tablet is crushed, a portion of the outer coating will break open so as to expose the gel-forming granule. The outer coating includes a material that resists dissolution when exposed to gastric fluids.
Claims38
A pharmaceutical composition, comprising:
- a. a therapeutic amount of an active ingredient;
- and
- b. at least one gel-forming granule that forms a gel when exposed to an aqueous liquid, the gel-forming granule coated with an outer coating that is sufficiently brittle so that when the tablet is crushed, a portion of the outer coating will break open so as to expose the gel-forming granule, the outer coating including a material that resists dissolution when exposed to gastric fluids.
A pharmaceutical tablet, comprising:
- a. a therapeutic amount of an active ingredient;
- and
- b. at least one gel-forming granule that forms a gel when exposed to an aqueous liquid;
- and
- c. an outer coating that coats the gel-forming granule and that is sufficiently brittle so that when the tablet is crushed, a portion of the outer coating will break open so as to expose the gel-forming granule, the outer coating including a material that resists dissolution when exposed to gastric fluids,
- the active ingredient, the gel-forming granule and the outer coating being compacted into a tablet form.
A pharmaceutical tablet, comprising:
- a. a granule including a therapeutic amount of an active ingredient;
- and
- b. at least one gel-forming granule that forms a gel when exposed to an aqueous liquid.
A method of inhibiting abuse of pharmaceutical compositions, comprising the steps of:
- a. coating a gel-forming granule, comprising a material that forms a gel when exposed to an aqueous liquid, with an outer coating that is sufficiently brittle so that when the tablet is crushed, a portion of the outer coating will break open so as to expose the gel-forming granule, the outer coating including a material that resists dissolution when exposed to gastric fluids;
- and
- b. mixing an active ingredient having a potential for abuse to the gel-forming granule.
An abuse-resistant pharmaceutical composition, comprising:
- a. a first plurality of granules of an active ingredient in a therapeutic amount;
- and
- b. a second plurality of granules, combined with the first plurality of granules, of a composition that interferes with abuse of the active ingredient when the first plurality of granules and the second plurality of granules are crushed.
Dependencies are inferred from the claim text.