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AssigneeMicronas Holding GmbH
InventorsMirko Lehmann, Claas Muller, Holger Klapproth, Ingo Freund
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Disclosed is a device for detecting at least one ligand contained in a sample that is to be analyzed. Said device comprises an optical waveguide, on the surface of which at least one ligand-specific receptor is directly or indirectly immobilized. The ligand bonds to said receptor during contact therewith. The inventive device comprises at least one optical source of radiation for injecting excitation radiation into the waveguide, the radiation being used for exciting emission of luminescence radiation in accordance with the bonding of the ligand to the receptor. At least one radiation receiver is integrated into the semiconductor substrate of a semiconductor chip so as to detect the luminescence radiation. The waveguide is integrated in a monolithic manner into the semiconductor substrate or is applied thereupon as a wave-guiding layer.
Device (1) for the detection of at least one ligand (2) contained in a sample that is to be analyzed, with an optical waveguide (4), on the surface of which at least one receptor (5) is directly or indirectly immobilized which, when it comes into contact with the ligand (2), forms a specific bond with the ligand (2), with at least one optical source of radiation (8) for injecting excitation radiation (9) into the waveguide (4), the radiation being used for exciting the emission of luminescence radiation (10) as a function of the bonding of the ligand (2) to the receptor (5), and with a semiconductor chip (3) that has at least one radiation receiver (12) on a semiconductor substrate to detect the luminescence radiation (10), characterized by the fact that the waveguide (4) is monolithically integrated with the semiconductor substrate or is located on the semiconductor (3).
Dependencies are inferred from the claim text.