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OwnerNancy Hong, Aude Fahrer +3inventors
InventorsNancy Hong, Aude Fahrer, Hua Wu, Richard Glynne, Christopher Goodnow
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The present invention relates to the discovery, identification, and characterization of novel genes encoding proteins that play a role in immune system development and function, collectively termed Nessie. The invention encompasses the described polynucleotides, the encoded proteins, fusion proteins, polypeptides and peptides, genetically engineered animals that either under- or over-express the disclosed sequences, antibodies to the encoded proteins and peptides, host cell expression systems, antagonists and agonists of the proteins, and other compounds that modulate the expression or activity of the proteins encoded by the disclosed sequences that can be used for diagnosis, drug screening, clinical trial monitoring and the treatment of diseases and disorders.
An isolated or recombinant nucleic acid comprising a nucleic acid sequence having at least about 70% sequence identity to SEQ ID NO:
An antisense oligonucleotide comprising a nucleic acid sequence complementary to or capable of hybridizing under stringent conditions to a nucleic acid sequence having at least about 70% sequence identity to SEQ ID NO:
A double stranded RNA oligonucleotide comprising a nucleic acid sequence complementary to or capable of hybridizing under stringent conditions to a nucleic acid sequence having at least about 70% sequence identity to SEQ ID NO:
An isolated or recombinant polypeptide comprising (i) an amino acid sequence having at least about 80% sequence identity to SEQ ID NO:
A transgenic non-human animal comprising a heterologous nucleic acid, wherein said nucleic acid comprises a sequence having at least about 70% sequence identity to SEQ ID NO:
A knockout non-human animal, wherein an endogenous gene sequence comprising a nucleic acid sequence having at least about 70% sequence identity to SEQ ID NO:
A non-human mammalian animal comprising a non-naturally occurring mutation in a Nessie gene.
Dependencies are inferred from the claim text.