Hydrophobic moment of multi-domain proteins
AssigneeInternational Business Machines Corporation
InventorsPrasanna Athma, Ajay Royyuru, Benjamin Silverman, Ruhong Zhou
Life of this patent
Estimating the term…
Abstract
Techniques for protein structure analysis are provided. In one aspect, a method of analyzing a multi-domain protein structure comprises the following steps. For at least one domain, a hydrophobic dipole, e.g., defined as a first-order hydrophobic moment of the domain, is calculated. A score representing the orientation of the hydrophobic dipole of the at least one domain relative to a hydrophobic dipole of one or more other domains of the multi-domain protein structure is then calculated.
Claims20
A method of analyzing a multi-domain protein structure, the method comprising the steps of:
- for at least one domain, calculating a hydrophobic dipole;
- and
- calculating a score representing the orientation of the hydrophobic dipole of the at least one domain relative to a hydrophobic dipole of one or more other domains of the multi-domain protein structure.
An apparatus for analyzing a multi-domain protein structure, the apparatus comprising:
- a memory;
- and
- at least one processor, coupled to the memory, operative to:
- for at least one domain, calculate a hydrophobic dipole;
- and
- calculate a score representing the orientation of the hydrophobic dipole of the at least one domain relative to a hydrophobic dipole of one or more other domains of the multi-domain protein structure.
An article of manufacture for analyzing a multi-domain protein structure, comprising a machine readable medium containing one or more programs which when executed implement the steps of:
- for at least one domain, calculating a hydrophobic dipole;
- and
- calculating a score representing the orientation of the hydrophobic dipole of the at least one domain relative to a hydrophobic dipole of one or more other domains of the multi-domain protein structure.
Dependencies are inferred from the claim text.