Mutants of streptococcal toxin A and methods of use
AssigneeRegents of the University of Minnesota
InventorsPatrick Schlievert, Manuela Roggiani, Jennifer Auge, Douglas Ohlendorf
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Abstract
This invention is directed to mutant SPE-A toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-A toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-A toxin. The mutant SPE-A toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-A toxin.
Claims18
A mutant SPE-A toxin or fragment thereof, wherein the mutant has at least one amino acid change and is substantially nonlethal compared with a protein substantially corresponding to wild type SPE-A toxin.
Dependencies are inferred from the claim text.