Cis-diiodo-(trans-l-1,2-cyclohexanediamine) platinum (II) complex and processes for preparing high purity oxaliplatin
AssigneeSicor Inc.
InventorsGuillermo Menez, Domenico Fimognari
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Abstract
The present invention is related to pure cis-diiodo-(trans-L-1,2-cyclohexanediamine) Pt (II) complex, and a process of its preparation. The present invention is further related to the preparation of oxaliplatin using said cis-diiodo-(trans-L-1,2-cyclohexanediamine) Pt (II) complex.
Claims33
Isolated cis-diiodo-(trans-L-1,2-cyclohexanediamine) Pt (II) complex of formula (2).
Cis-diiodo-(trans-L-1,2-cyclohexanediamine) Pt (II) complex, wherein the level of the cis-diiodo-(trans-D-1,2-cyclohexanediamine) Pt (II) complex isomer is less than about 3% area by HPLC.
A process for preparing cis-diiodo-(trans-L-1,2-cyclohexanediamine) Pt (II) complex comprising:
- a) combining trans-L-1,2-cyclohexanediamine of the formula (5)
- with M2PtX4 and KI, to obtain a mixture;
- b) maintaining the mixture at room temperature;
- and
- c) recovering cis-diiodo-(trans-L-1,2-cyclohexanediamine) Pt (II) complex,
- wherein M is Li, Na or K, and
- wherein X is I, Cl or Br.
A process for preparing oxaliplatin comprising the steps of:
- a) combining an aqueous solution of trans-L-1,2-cyclohexanediamine of the formula (5)
- with an aqueous solution of M2PtX4 and KI, to obtain a mixture;
- b) maintaining the mixture at room temperature;
- c) recovering cis-diiodo-(trans-L-1,2-cyclohexanediamine) Pt (II) complex;
- and
- d) converting the cis-diiodo-(trans-L-1,2-cyclohexanediamine) Pt (II) complex into oxaliplatin,
- wherein M is Li, Na or K, and
- wherein X is I, Cl or Br.
Dependencies are inferred from the claim text.