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US 2006/0041008 A1Published application
Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
AssigneeJanssen Pharmaceutica NV
InventorsDavid McComsey, Michael Parker, Allen Reitz, Bruce Maryanoff
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Abstract
The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.
Claims15
A compound of formula (II)
- wherein
- R1 and R2 are each independently selected from the group consisting of hydrogen and lower alkyl;
- R4 is selected from the group consisting of hydrogen and lower alkyl;
- a is an integer from 1 to 2;
- is selected from the group consisting of
- wherein b is an integer from 0 to 4;
- and wherein c is an integer from 0 to 2;
- each R5 is independently selected from the group consisting of halogen, lower alkyl and nitro;
- provided that when
- then a is 1;
- or a pharmaceutically acceptable salt thereof.
8 more elements
A compound selected from the group consisting of N-[(6-chloro-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-sulfamide and pharmaceutically acceptable salts thereof.
A compound selected from the group consisting of
- and pharmaceutically acceptable salts thereof.
A compound of the formula (III)
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.