Guanylhydrazone compounds, compositions, methods of making and using

A compound, having the formula:

• or a salt thereof;
• wherein X1, X2, X3, and X4 each independently represent H, GhyCH—, GhyCCH3—, or CH3CO—, with the provisos that X1, X2, X3 and X4 are not simultaneously H;
• wherein Z is one or more selected from the group consisting of:
• -(A1)a-(CR2R3)x-(A2)b-;
• -(A1)a-(CR2R3)x-Qm-(CR4R5)y-(A2)b-;
• and
• -(A1)a-(CR2R3)x-Qm-(CR4R5)y-Tn-(CR6R7)z-(A2)b-;
• and combinations thereof;
• wherein a is selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, and 9;
• wherein b is selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, and 9;
• wherein x is selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, and 9;
• wherein y is selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, and 9;
• wherein z is selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, and 9;
• wherein m is selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, and 9;
• wherein n is selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, 8, and 9;
• wherein A1 and A2 are each independently selected from the group consisting of —NR8(CO)NR9—, —(CO)NR8—, —NR8(CO)—, —NR8—, —O—, —S—, —S(═O)—, —SO2—, —SO2NR8—, —NR8SO2—, and salts thereof;
• wherein Q and T are each independently selected from the group consisting of —NR10(CO)NR11—, —(CO)NR10—, —NR10(CO)—, —NR10—, —O—, —S—, —S(═O)—, —SO2—, —SO2NR10—, —NR10SO2—, salts thereof, branched or unbranched, saturated or unsaturated, substituted or unsubstituted C1-C20 alkylene, saturated or unsaturated, substituted or unsubstituted C3-C20 cycloalkylene, substituted or unsubstituted C5-C25 arylene, and combinations thereof;
• wherein one or more carbon atoms in any of said alkylene, cycloalkylene or arylene in said Q and/or T may each be independently replaced with one or more heteroatoms selected from the group consisting of nitrogen, oxygen, sulfur, and a combination thereof;
• and wherein when substituted, said alkylene, cycloalkylene or arylene in said Q and/or T are each independently substituted with one or more substituent groups selected from the group consisting of hydroxy, halo, bromo, chloro, iodo, fluoro, —N3, —CN, —NC, —SH, —NO2, —NH2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclic, (C2-C20)alkenyl, (C3-C20)cycloalkenyl, (C2-C20)alkynyl, (C5-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, (C1-C20)alkyl-O—, phenyl-O—, (C3-C20)cycloalkyl-O—, (C3-C25)heteroaryl-O—, (C3-C25)heterocyclic-O—, (C2-C20)alkenyl-O—, (C3-C20)cycloalkenyl-O—, (C2-C20)alkynyl-O—, (C5-C20)cycloalkynyl-O—, (C5-C25)aryl-O—, perhalo(C1-C20)alkyl-O—, (C1-C20)alkyl-S—, phenyl-S—, (C3-C20)cycloalkyl-S—, (C3-C25)heteroaryl-S—, (C3-C25)heterocyclic-S—, (C2-C20)alkenyl-S—, (C3-C20)cycloalkenyl-S—, (C2-C20)alkynyl-S—, (C5-C20)cycloalkynyl-S—, (C5-C25)aryl-S—, perhalo(C1-C20)alkyl-S—, (C1-C20)alkyl-SO2—, phenyl-SO2—, (C3-C20)cycloalkyl-SO2—, (C1-C20)alkoxy-SO2—, (C3-C25)heteroaryl-SO2—, (C3-C25)heterocyclic-SO2—, (C2-C20)alkenyl-SO2—, (C3-C20)cycloalkenyl-SO2—, (C2-C20)alkynyl-SO2—, (C5-C20)cycloalkynyl-SO2—, (C5-C25)aryl-SO2—, perhalo(C1-C20)alkyl-SO2—, H2N—SO2—, (C1-C20)alkyl-NH—SO2—, phenyl-NH—SO2—, (C3-C20)cycloalkyl-NH—SO2—, (C1-C20)alkoxy-NH—SO2—, (C3-C25)heteroaryl-NH—SO2—, (C3-C25)heterocyclic-NH—SO2—, (C2-C20)alkenyl-NH—SO2—, (C3-C20)cycloalkenyl-NH—SO2—, (C2-C20)alkynyl-NH—SO2—, (C5-C20)cycloalkynyl-NH—SO2—, (C5-C25)aryl-NH—SO2—, perhalo(C1-C20)alkyl-NH—SO2—, {(C1-C20)alkyl}2N—SO2—, {phenyl}2N—SO2—, {(C3-C20)cycloalkyl}2N—SO2—, {(C1-C20)alkoxy}2N—SO2—, {(C3-C25)heteroaryl}2N—SO2—, {(C3-C25)heterocyclic}2N—SO2—, {(C2-C20)alkenyl}2N—SO2—, {(C2-C20)alkynyl}2N—SO2—, {(C5-C20)cycloalkynyl}2N—SO2—, {(C5-C25)aryl}2N—SO2—, {perhalo(C1-C20)alkyl}2N—SO2—, (C1-20)alkyl-SO2—NH—, phenyl-SO2—NH—, (C3-C20)cycloalkyl-SO2—NH—, (C1-C20)alkoxy-SO2—NH—, (C3-C25)heteroaryl-SO2—NH—, (C3-C25)heterocyclic-SO2—NH—, (C2-C20)alkenyl-SO2—NH—, (C3-C20)cycloalkenyl-SO2—NH—, (C2-C20)alkynyl-SO2—NH—, (C5-C20)cycloalkynyl-SO2—NH—, (C5-C25)aryl-SO2—NH—, perhalo(C1-C20)alkyl-SO2—NH—, (C1-C20)alkyl-NH—, phenyl-NH—, (C3-C20)cycloalkyl-NH—, (C1-C20)alkoxy-NH—, (C3-C25)heteroaryl-NH—, (C3-C25)heterocyclic-NH—, (C2-C20)alkenyl-NH—, (C3-C20)cycloalkenyl-NH—, (C2-C20)alkynyl-NH—, (C5-C20)cycloalkynyl-NH—, (C5-C25)aryl-NH—, perhalo(C1-C20)alkyl-NH—, {(C1-C20)alkyl}2N—, {phenyl}2N—, {(C3-C20)cycloalkyl}2N—, {(C1-C20)alkoxy}2N—, {(C3-C25)heteroaryl}2N—, {(C3-C25)heterocyclic}2N—, {(C2-C20)alkenyl}2N—, {(C3-C20)cycloalkenyl}2N—, {(C2-C20)alkynyl}2N—, {(C5-C20)cycloalkynyl}2N—, {(C5-C25)aryl}2N—, {perhalo(C1-C20)alkyl}2N—, (C1-C20)alkyl-(C═O)—NH—, phenyl-(C═O)—NH—, (C3-C20)cycloalkyl-(C═O)—NH—, (C1-C20)alkoxy-(C═O)—NH—, (C3-C25)heteroaryl-(C═O)—NH—, (C3-C25)heterocyclic-(C═O)—NH—, (C2-C20)alkenyl-(C═O)—NH—, (C3-C20)cycloalkenyl-(C═O)—NH—, (C2-C20)alkynyl-(C═O)—NH—, (C5-C20)cycloalkynyl-(C═O)—NH—, (C5-C25)aryl-(C═O)—NH—, perhalo(C1-C20)alkyl-(C═O)—NH—, (C1-C20)alkyl-C═O)—{((C1-C20)alkyl)N}—, phenyl-(C═O)—{((C1-C20)alkyl)N}—, (C3-C20)cycloalkyl-(C═O)—{((C1-C20)alkyl)N}—, (C1-C20)alkoxy-(C═O)—{((C1-C20)alkyl)N}—, (C3-C25)heteroaryl-(C═O)—{((C1-C20)alkyl)N}—, (C3-C25)heterocyclic-(C═O)—{((C1-C20)alkyl)N}—, (C2-C20)alkenyl-(C═O)—{((C1-C20)alkyl)N}—, (C3-C20)cycloalkenyl-(C═O)—{((C1-C20)alkyl)N}—, (C2-C20)alkynyl-(C═O)—{((C1-C20)alkyl)N}—, (C5-C20)cycloalkynyl-(C═O)—{((C1-C20)alkyl)N}—, (C5-C25)aryl-(C═O)—{((C1-C20)alkyl)N}—, perhalo(C1-C20)alkyl-(C═O)—{((C1-C20)alkyl)N}—, phenyl-(C═O)—NH—, phenyl-(C═O)-{(phenyl)N}—, (C1-C20)alkyl-(C═O)-{(phenyl)N}—, (C3-C20)cycloalkyl-(C═O)-{(phenyl)N}—, (C1-C20)alkoxy-(C═O)-{(phenyl)N}—, (C3-C25)heteroaryl-(C═O)-{(phenyl)N}—, (C3-C25)heterocyclic-(C═O)-{(phenyl)N}—, (C2-C20)alkenyl-(C═O)-{(phenyl)N}—, (C3-C20)cycloalkenyl-(C═O)-{(phenyl)N}—, (C2-C20)alkynyl-(C═O)-{(phenyl)N}—, (C5-C20)cycloalkynyl-(C═O)-{(phenyl)N}—, (C5-C25)aryl-(C═O)-{(phenyl)N}—, perhalo(C1-C20)alkyl-(C═O)-{(phenyl)N}—, H2N(C═O)—, (C1-C20)alkyl-NH—(C═O)—, phenyl-NH—(C═O)—, (C3-C20)cycloalkyl-NH—(C═O)—, (C1-C20)alkoxy-NH—(C═O)—, (C3-C25)heteroaryl-NH—(C═O)—, (C3-C25)heterocyclic-NH—(C═O)—, (C2-C20)alkenyl-NH—(C═O)—, (C3-C20)cycloalkenyl-NH—(C═O)—, (C2-C20)alkynyl-NH—(C═O)—, (C5-C20)cycloalkynyl-NH—(C═O)—, (C5-C25)aryl-NH—(C═O)—, perhalo(C1-C20)alkyl-NH—(C═O)—, {C1-C20)alkyl}2N—(C═O)—, {phenyl}{(C1-C20)alkyl}N—(C═O)—, {(C3-C20)cycloalkyl}{(C1-C20)alkyl}N—(C═O)—, {(C1-C20)alkoxy}{(C1-C20)alkyl}N—(C═O)—, {(C3-C25)heteroaryl}{(C1-C20)alkyl}N—(C═O)—, {(C3-C25)heterocyclic}{(C1-C20)alkyl}N—(C═O)—, {(C2-C20)alkenyl}{(C1-C20)alkyl}N—(C═O)—, {(C3-C20)cycloalkenyl}{(C1-C20)alkyl}N—(C═O)—, {(C2-C20)alkynyl}{(C1-C20)alkyl}N—(C═O)—, {(C5-C20)cycloalkynyl}{(C1-C20)alkyl}N—(C═O)—, {(C5-C25)aryl}{(C1-C20)alkyl}N—(C═O)—, {perhalo(C1-C20)alkyl}{(C1-C20)alkyl}N—(C═O)—, {phenyl}2N—(C═O)—, {(C3-C20)cycloalkyl}{phenyl}N—(C═O)—, {(C1-C20)alkoxy}{phenyl}N—(C═O)—,{(C3-C25)heteroaryl}{phenyl}N—(C═O)—, {(C3-C25)heterocyclic}{phenyl}N—(C═O)—, {(C2-C20)alkenyl}{phenyl}N—(C═O)—, {(C3-C20)cycloalkenyl}{phenyl}N—(C═O)—, {(C2-C20)alkynyl}{phenyl}N—(C═O)—, {(C5-C20)cycloalkynyl}{phenyl}N—(C═O)—, {(C5-C25)aryl}{phenyl}N—(C═O)—, {perhalo(C1-C20)alkyl}{phenyl}N—(C═O)—, HO—(C═O)—, (C1-C20)alkyl-(C═O)—, (C3-C25)heteroaryl-(C═O)—, (C3-C25)heterocyclic-(C═O)—, (C2-C20)alkenyl-(C═O)—, (C3-C20)cycloalkenyl-(C═O)—, (C2-C20)alkynyl-(C═O)—, (C5-C25)aryl-(C═O)—, perhalo(C1-C20)alkyl-(C═O)—, phenyl-(C═O)—, (C1-C20)alkyl-O—(C═O)—, (C3-C25)heteroaryl-O—(C═O)—, (C3-C25)heterocyclic-O—(C═O)—, (C2-C20)alkenyl-O—(C═O)—, (C3-C20)cycloalkenyl-O—(C═O)—, (C2-C20)alkynyl-O—(C═O)—, (C5-C25)aryl-O—(C═O)—, perhalo(C1-C20)alkyl-O—(C═O)—, phenyl-O—(C═O)—, (C1-C20)alkyl-(C═O)—O—, (C3-C25)heteroaryl-(C═O)—O—, (C3-C25)heterocyclic-(C═O)—O—, (C2-C20)alkenyl-(C═O)—O—, (C3-C20)cycloalkenyl-(C═O)—O—, (C2-C20)alkynyl-(C═O)—O—, (C5-C25)aryl-(C═O)—O—, phenyl-(C═O)—O—, perhalo(C1-C20)alkyl-(C═O)—O—, and salts thereof;
• wherein each of the aforesaid (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (Chd 20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclic, (C2-C20)alkenyl, (C3-C20)cycloalkenyl, (C2-C20)alkynyl, (C5-C20)cycloalkynyl, and (C5-C25)aryl groups (as substituents on said alkylene, cycloalkylene or arylene of said Q and T) may be optionally and independently substituted by one to four moieties selected from the group consisting of hydroxy, halo, bromo, chloro, iodo, fluoro, —N3, —CN, —NC, —SH, —NO2, —NH2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclic, (C2-C20)alkenyl, (C3-C20)cycloalkenyl, (C2-C20)alkynyl, (C5-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, (C1-C20)alkyl-O—, phenyl-O—, (C3-C20)cycloalkyl-O—, (C3-C25)heteroaryl-O—, (C3-C25)heterocyclic-O—, (C2-C20)alkenyl-O—, (C3-C20)cycloalkenyl-O—, (C2-C20)alkynyl-O—, (C5-C20)cycloalkynyl-O—, (C5-C25)aryl-O—, perhalo(C1-C20)alkyl-O—, (C1-C20)alkyl-S—, phenyl-S—, (C3-C20)cycloalkyl-S—, (C3-C25)heteroaryl-S—, (C3-C25)heterocyclic-S—, (C2-C20)alkenyl-S—, (C3-C20)cycloalkenyl-S—, (C2-C20)alkynyl-S—, (C5-C20)cycloalkynyl-S—, (C5-C25)aryl-S—, perhalo(C1-C20)alkyl-S—, (C1-C20)alkyl-SO2—, phenyl-SO2—, (C3-C20)cycloalkyl-SO2—, (C1-C20)alkoxy-SO2—, (C3-C25)heteroaryl-SO2—, (C3-C25)heterocyclic-SO2—, (C2-C20)alkenyl-SO2—, (C3-C20)cycloalkenyl-SO2—, (C2-C20)alkynyl-SO2—, (C5-C20)cycloalkynyl-SO2—, (C5-C25)aryl-SO2—, perhalo(C1-C20)alkyl-SO2—, H2N—SO2—, (C1-C20)alkyl-NH—SO2—, phenyl-NH—SO2—, (C3-C20)cycloalkyl-NH—SO2—, (C1-C20)alkoxy-NH—SO2—, (C3-C25)heteroaryl-NH—SO2—, (C3-C25)heterocyclic-NH—SO2—, (C2-C20)alkenyl-NH—SO2—, (C3-C20)cycloalkenyl-NH—SO2—, (C2-C20)alkynyl-NH—SO2—, (C5-C20)cycloalkynyl-NH—SO2—, (C5-C25)aryl-NH—SO2—, perhalo(C1-C20)alkyl-NH—SO2—, {(C1-C20)alkyl}2N—SO2—, {phenyl}2N—SO2—, {(C3-C20)cycloalkyl}2N—SO2—, {(C1-C20)alkoxy}2N—SO2—, {(C3-C25)heteroaryl}2N—SO2—, {(C3-C25)heterocyclic}2N—SO2—, {(C2-C20)alkenyl}2N—SO2—, {(C2-C20)alkynyl}2N—SO2—, {(C5-C20)cycloalkynyl}2N—SO2—, {(C5-C25)aryl}2N—SO2—, {perhalo(C1-C20)alkyl}2N—SO2—, (C1-20)alkyl-SO2—NH—, phenyl-SO2—NH—, (C3-C20)cycloalkyl-SO2—NH—, (C1-C20)alkoxy-SO2—NH—, (C3-C25)heteroaryl-SO2—NH—, (C3-C25)heterocyclic-SO2—NH—, (C2-C20)alkenyl-SO2—NH—, (C3-C20)cycloalkenyl-SO2—NH—, (C2-C20)alkynyl-SO2—NH—, (C5-C20)cycloalkynyl-SO2—NH—, (C5-C25)aryl-SO2—NH—, perhalo(C1-C20)alkyl-SO2—NH—, (C1-C20)alkyl-NH—, phenyl-NH—, (C3-C20)cycloalkyl-NH—, (C1-C20)alkoxy-NH—, (C3-C25)heteroaryl-NH—, (C3-C25)heterocyclic-NH—, (C2-C20)alkenyl-NH—, (C3-C20)cycloalkenyl-NH—, (C2-C20)alkynyl-NH—, (C5-C20)cycloalkynyl-NH—, (C5-C25)aryl-NH—, perhalo(C1-C20)alkyl-NH—, {(C1-C20)alkyl}2N—, {phenyl}2N—, {(C3-C20)cycloalkyl}2N—, {(C1-C20)alkoxy}2N—, {(C3-C25)heteroaryl}2N—, {(C3-C25)heterocyclic}2N—, {(C2-C20)alkenyl}2N—, {(C3-C20)cycloalkenyl}2N—, {(C2-C20)alkynyl}2N—, {(C5-C20)cycloalkynyl}2N—, {(C5-C25)aryl}2N—, {perhalo(C1-C20)alkyl}2N—, (C1-C20)alkyl-(C═O)—NH—, phenyl-(C═O)—NH—, (C3-C20)cycloalkyl-(C═O)—NH—, (C1-C20)alkoxy-(C═O)—NH—, (C3-C25)heteroaryl-(C═O)—NH—, (C3-C25)heterocyclic-(C═O)—NH—, (C2-C20)alkenyl-(C═O)—NH—, (C3-C20)cycloalkenyl-(C═O)—NH—, (C2-C20)alkynyl-(C═O)—NH—, (C5-C20)cycloalkynyl-(C═O)—NH—, (C5-C25)aryl-(C═O)—NH—, perhalo(C1-C20)alkyl-(C═O)—NH—, (C1-C20)alkyl-C═O)—{((C1-C20)alkyl)N}—, phenyl-(C═O)—{((C1-C20)alkyl)N}—, (C3-C20)cycloalkyl-(C═O)—{((C1-C20)alkyl)N}—, (C1-C20)alkoxy-(C═O)—{((C1-C20)alkyl)N}—, (C3-C25)heteroaryl-(C═O)—{((C1-C20)alkyl)N}—, (C3-C25)heterocyclic-(C═O)—{((C1-C20)alkyl)N}—, (C2-C20)alkenyl-(C═O)—{((C1-C20)alkyl)N}—, (C3-C20)cycloalkenyl-(C═O)—{((C1-C20)alkyl)N}—, (C2-C20)alkynyl-(C═O)—{((C1-C20)alkyl)N}—, (C5-C20)cycloalkynyl-(C═O)—{((C1-C20)alkyl)N}—, (C5-C25)aryl-(C═O)—{((C1-C20)alkyl)N}—, perhalo(C1-C20)alkyl-(C═O)—{((C1-C20)alkyl)N}—, phenyl-(C═O)—NH—, phenyl-(C═O)-{(phenyl)N}—, (C1-C20)alkyl-(C═O)-{(phenyl)N}—, (C3-C20)cycloalkyl-(C═O)-{(phenyl)N}—, (C1-C20)alkoxy-(C═O)-{(phenyl)N}—, (C3-C25)heteroaryl-(C═O)-{(phenyl)N}—, (C3-C25)heterocyclic-(C═O)-{(phenyl)N}—, (C2-C20)alkenyl-(C═O)-{(phenyl)N}—, (C3-C20)cycloalkenyl-(C═O)-{(phenyl)N}—, (C2-C20)alkynyl-(C═O)-{(phenyl)N}—, (C5-C20)cycloalkynyl-(C═O)-{(phenyl)N}—, (C5-C25)aryl-(C═O)-{(phenyl)N}—, perhalo(C1-C20)alkyl-(C═O)-{(phenyl)N}—, H2N(C═O)—, (C1-C20)alkyl-NH—(C═O)—, phenyl-NH—(C═O)—, (C3-C20)cycloalkyl-NH—(C═O)—, (C1-C20)alkoxy-NH—(C═O)—, (C3-C25)heteroaryl-NH—(C═O)—, (C3-C25)heterocyclic-NH—(C═O)—, (C2-C20)alkenyl-NH—(C═O)—, (C3-C20)cycloalkenyl-NH—(C═O)—, (C2-C20)alkynyl-NH—(C═O)—, (C5-C20)cycloalkynyl-NH—(C═O)—, (C5-C25)aryl-NH—(C═O)—, perhalo(C1-C20)alkyl-NH—(C═O)—, {C1-C20)alkyl}2N—(C═O)—, {phenyl}{(C1-C20)alkyl}N—(C═O)—, {(C3-C20)cycloalkyl}{(C1-C20)alkyl}N—(C═O)—, {(C1-C20)alkoxy}{(C1-C20)alkyl}N—(C═O)—, {(C3-C25)heteroaryl}{(C1-C20)alkyl}N—(C═O)—, {(C3-C25)heterocyclic}{(C1-C20)alkyl}N—(C═O)—, {(C2-C20)alkenyl}{(C1-C20)alkyl}N—(C═O)—, {(C3-C20)cycloalkenyl}{(C1-C20)alkyl}N—(C═O)—, {(C2-C20)alkynyl}{(C1-C20)alkyl}N—(C═O)—, {(C5-C20)cycloalkynyl}{(C1-C20)alkyl}N—(C═O)—, {(C5-C25)aryl}{(C1-C20)alkyl}N—(C═O)—, {perhalo(C1-C20)alkyl}{(C1-C20)alkyl}N—(C═O)—, {phenyl}2N—(C═O)—, {(C3-C20)cycloalkyl}{phenyl}N—(C═O)—, {(C1-C20)alkoxy}{phenyl}N—(C═O)—,{(C3-C25)heteroaryl}{phenyl}N—(C═O)—, {(C3-C25)heterocyclic}{phenyl}N—(C═O)—, {(C2-C20)alkenyl}{phenyl}N—(C═O)—, {(C3-C20)cycloalkenyl}{phenyl}N—(C═O)—, {(C2-C20)alkynyl}{phenyl}N—(C═O)—, {(C5-C20)cycloalkynyl}{phenyl}N—(C═O)—, {(C5-C25)aryl}{phenyl}N—(C═O)—, {perhalo(C1-C20)alkyl}{phenyl}N—(C═O)—, HO—(C═O)—,(C1-C20)alkyl-(C═O)—, (C3-C25)heteroaryl-(C═O)—, (C3-C25)heterocyclic-(C═O)—, (C2-C20)alkenyl-(C═O)—, (C3-C20)cycloalkenyl-(C═O)—, (C2-C20)alkynyl-(C═O)—, (C5-C25)aryl-(C═O)—, perhalo(C1-C20)alkyl-(C═O)—, phenyl-(C═O)—, (C1-C20)alkyl-O—(C═O)—, (C3-C25)heteroaryl-O—(C═O)—, (C3-C25)heterocyclic-O—(C═O)—, (C2-C20)alkenyl-O—(C═O)—, (C3-C20)cycloalkenyl-O—(C═O)—, (C2-C20)alkynyl-O—(C═O)—, (C5-C25)aryl-O—(C═O)—, perhalo(C1-C20)alkyl-O—(C═O)—, phenyl-O—(C═O)—, (C1-C20)alkyl-(C═O)—O—, (C3-C25)heteroaryl-(C═O)—O—, (C3-C25)heterocyclic-(C═O)—O—, (C2-C20)alkenyl-(C═O)—O—, (C3-C20)cycloalkenyl-(C═O)—O—, (C2-C20)alkynyl-(C═O)—O—, (C5-C25)aryl-(C═O)—O—, phenyl-(C═O)—O—, perhalo(C1-C20)alkyl-(C═O)—O—, and salts thereof;
• and
• wherein R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are each independently selected from the group consisting of hydrogen, hydroxy, halo, bromo, chloro, iodo, fluoro, —N3, —CN, —NC, —SH, —NO2, —NH2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclic, (C2-C20)alkenyl, (C3-C20)cycloalkenyl, (C2-C20)alkynyl, (C5-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, (C1-C20)alkyl-O—, phenyl-O—, (C3-C20)cycloalkyl-O—, (C3-C25)heteroaryl-O—, (C3-C25)heterocyclic-O—, (C2-C20)alkenyl-O—, (C3-C20)cycloalkenyl-O—, (C2-C20)alkynyl-O—, (C5-C20)cycloalkynyl-O—, (C5-C25)aryl-O—, perhalo(C1-C20)alkyl-O—, (C1-C20)alkyl-S—, phenyl-S—, (C3-C20)cycloalkyl-S—, (C3-C25)heteroaryl-S—, (C3-C25)heterocyclic-S—, (C2-C20)alkenyl-S—, (C3-C20)cycloalkenyl-S—, (C2-C20)alkynyl-S—, (C5-C20)cycloalkynyl-S—, (C5-C25)aryl-S—, perhalo(C1-C20)alkyl-S—, (C1-C20)alkyl-SO2—, phenyl-SO2—, (C3-C20)cycloalkyl-SO2—, (C1-C20)alkoxy-SO2—, (C3-C25)heteroaryl-SO2—, (C3-C25)heterocyclic-SO2—, (C2-C20)alkenyl-SO2—, (C3-C20)cycloalkenyl-SO2—, (C2-C20)alkynyl-SO2—, (C5-C20)cycloalkynyl-SO2—, (C5-C25)aryl-SO2—, perhalo(C1-C20)alkyl-SO2—, H2N—SO2—, (C1-C20)alkyl-NH—SO2—, phenyl-NH—SO2—, (C3-C20)cycloalkyl-NH—SO2—, (C1-C20)alkoxy-NH—SO2—, (C3-C25)heteroaryl-NH—SO2—, (C3-C25)heterocyclic-NH—SO2—, (C2-C20)alkenyl-NH—SO2—, (C3-C20)cycloalkenyl-NH—SO2—, (C2-C20)alkynyl-NH—SO2—, (C5-C20)cycloalkynyl-NH—SO2—, (C5-C25)aryl-NH—SO2—, perhalo(C1-C20)alkyl-NH—SO2—, {(C1-C20)alkyl}2N—SO2—, {phenyl}2N—SO2—, {(C3-C20)cycloalkyl}2N—SO2—, {(C1-C20)alkoxy}2N—SO2—, {(C3-C25)heteroaryl}2N—SO2—, {(C3-C25)heterocyclic}2N—SO2—, {(C2-C20)alkenyl}2N—SO2—, {(C2-C20)alkynyl}2N—SO2—, {(C5-C20)cycloalkynyl}2N—SO2—, {(C5-C25)aryl}2N—SO2—, {perhalo(C1-C20)alkyl}2N—SO2—, (C1-20)alkyl-SO2—NH—, phenyl-SO2—NH—, (C3-C20)cycloalkyl-SO2—NH—, (C1-C20)alkoxy-SO2—NH—, (C3-C25)heteroaryl-SO2—NH—, (C3-C25)heterocyclic-SO2—NH—, (C2-C20)alkenyl-SO2—NH—, (C3-C20)cycloalkenyl-SO2—NH—, (C2-C20)alkynyl-SO2—NH—, (C5-C20)cycloalkynyl-SO2—NH—, (C5-C25)aryl-SO2—NH—, perhalo(C1-C20)alkyl-SO2—NH—, (C1-C20)alkyl-NH—, phenyl-NH—, (C3-C20)cycloalkyl-NH—, (C1-C20)alkoxy-NH—, (C3-C25)heteroaryl-NH—, (C3-C25)heterocyclic-NH—, (C2-C20)alkenyl-NH—, (C3-C20)cycloalkenyl-NH—, (C2-C20)alkynyl-NH—, (C5-C20)cycloalkynyl-NH—, (C5-C25)aryl-NH—, perhalo(C1-C20)alkyl-NH—, {(C1-C20)alkyl}2N—, {phenyl}2N—, {(C3-C20)cycloalkyl}2N—, {(C1-C20)alkoxy}2N—, {(C3-C25)heteroaryl}2N—, {(C3-C25)heterocyclic}2N—, {(C2-C20)alkenyl}2N—, {(C3-C20)cycloalkenyl}2N—, {(C2-C20)alkynyl}2N—, {(C5-C20)cycloalkynyl}2N—, {(C5-C25)aryl}2N—, {perhalo(C1-C20)alkyl}2N—, (C1-C20)alkyl-(C═O)—NH—, phenyl-(C═O)—NH—, (C3-C20)cycloalkyl-(C═O)—NH—, (C1-C20)alkoxy-(C═O)—NH—, (C3-C25)heteroaryl-(C═O)—NH—, (C3-C25)heterocyclic-(C═O)—NH—, (C2-C20)alkenyl-(C═O)—NH—, (C3-C20)cycloalkenyl-(C═O)—NH—, (C2-C20)alkynyl-(C═O)—NH—, (C5-C20)cycloalkynyl-(C═O)—NH—, (C5-C25)aryl-(C═O)—NH—, perhalo(C1-C20)alkyl-(C═O)—NH—, (C1-C20)alkyl-C═O)—{((C1-C20)alkyl)N}—, phenyl-(C═O)—{((C1-C20)alkyl)N}—, (C3-C20)cycloalkyl-(C═O)—{((C1-C20)alkyl)N}—, (C1-C20)alkoxy-(C═O)—{((C1-C20)alkyl)N}—, (C3-C25)heteroaryl-(C═O)—{((C1-C20)alkyl)N}—, (C3-C25)heterocyclic-(C═O)—{((C1-C20)alkyl)N}—, (C2-C20)alkenyl-(C═O)—{((C1-C20)alkyl)N}—, (C3-C20)cycloalkenyl-(C═O)—{((C1-C20)alkyl)N}—, (C2-C20)alkynyl-(C═O)—{((C1-C20)alkyl)N}—, (C5-C20)cycloalkynyl-(C═O)—{((C1-C20)alkyl)N}—, (C5-C25)aryl-(C═O)—{((C1-C20)alkyl)N}—, perhalo(C1-C20)alkyl-(C═O)—{((C1-C20)alkyl)N}—, phenyl-(C═O)—NH—, phenyl-(C═O)-{(phenyl)N}—, (C1-C20)alkyl-(C═O)-{(phenyl)N}—, (C3-C20)cycloalkyl-(C═O)-{(phenyl)N}—, (C1-C20)alkoxy-(C═O)-{(phenyl)N}—, (C3-C25)heteroaryl-(C═O)-{(phenyl)N}—, (C3-C25)heterocyclic-(C═O)-{(phenyl)N}—, (C2-C20)alkenyl-(C═O)-{(phenyl)N}—, (C3-C20)cycloalkenyl-(C═O)-{(phenyl)N}—, (C2-C20)alkynyl-(C═O)-{(phenyl)N}—, (C5-C20)cycloalkynyl-(C═O)-{(phenyl)N}—, (C5-C25)aryl-(C═O)-{(phenyl)N}—, perhalo(C1-C20)alkyl-(C═O)-{(phenyl)N}—, H2N(C═O)—, (C1-C20)alkyl-NH—(C═O)—, phenyl-NH—(C═O)—, (C3-C20)cycloalkyl-NH—(C═O)—, (C1-C20)alkoxy-NH—(C═O)—, (C3-C25)heteroaryl-NH—(C═O)—, (C3-C25)heterocyclic-NH—(C═O)—, (C2-C20)alkenyl-NH—(C═O)—, (C3-C20)cycloalkenyl-NH—(C═O)—, (C2-C20)alkynyl-NH—(C═O)—, (C5-C20)cycloalkynyl-NH—(C═O)—, (C5-C25)aryl-NH—(C═O)—, perhalo(C1-C20)alkyl-NH—(C═O)—, {C1-C20)alkyl}2N—(C═O)—, {phenyl}{(C1-C20)alkyl}N—(C═O)—, {(C3-C20)cycloalkyl}{(C1-C20)alkyl}N—(C═O)—, {(C1-C20)alkoxy}{(C1-C20)alkyl}N—(C═O)—, {(C3-C25)heteroaryl}{(C1-C20)alkyl}N—(C═O)—, {(C3-C25)heterocyclic}{(C1-C20)alkyl}N—(C═O)—, {(C2-C20)alkenyl}{(C1-C20)alkyl}N—(C═O)—, {(C3-C20)cycloalkenyl}{(C1-C20)alkyl}N—(C═O)—, {(C2-C20)alkynyl}{(C1-C20)alkyl}N—(C═O)—, {(C5-C20)cycloalkynyl}{(C1-C20)alkyl}N—(C═O)—, {(C5-C25)aryl}{(C1-C20)alkyl}N—(C═O)—, {perhalo(C1-C20)alkyl}{(C1-C20)alkyl}N—(C═O)—, {phenyl}2N—(C═O)—, {(C3-C20)cycloalkyl}{phenyl}N—(C═O)—, {(C1-C20)alkoxy}{phenyl}N—(C═O)—,{(C3-C25)heteroaryl}{phenyl}N—(C═O)—, {(C3-C25)heterocyclic}{phenyl}N—(C═O)—, {(C2-C20)alkenyl}{phenyl}N—(C═O)—, {(C3-C20)cycloalkenyl}{phenyl}N—(C═O)—, {(C2-C20)alkynyl}{phenyl}N—(C═O)—, {(C5-C20)cycloalkynyl}{phenyl}N—(C═O)—, {(C5-C25)aryl}{phenyl}N—(C═O)—, {perhalo(C1-C20)alkyl}{phenyl}N—(C═O)—, HO—(C═O)—,(C1-C20)alkyl-(C═O)—, (C3-C25)heteroaryl-(C═O)—, (C3-C25)heterocyclic-(C═O)—, (C2-C20)alkenyl-(C═O)—, (C3-C20)cycloalkenyl-(C═O)—, (C2-C20)alkynyl-(C═O)—, (C5-C25)aryl-(C═O)—, perhalo(C1-C20)alkyl-(C═O)—, phenyl-(C═O)—, (C1-C20)alkyl-O—(C═O)—, (C3-C25)heteroaryl-O—(C═O)—, (C3-C25)heterocyclic-O—(C═O)—, (C2-C20)alkenyl-O—(C═O)—, (C3-C20)cycloalkenyl-O—(C═O)—, (C2-C20)alkynyl-O—(C═O)—, (C5-C25)aryl-O—(C═O)—, perhalo(C1-C20)alkyl-O—(C═O)—, phenyl-O—(C═O)—, (C1-C20)alkyl-(C═O)—O—, (C3-C25)heteroaryl-(C═O)—O—, (C3-C25)heterocyclic-(C═O)—O—, (C2-C20)alkenyl-(C═O)—O—, (C3-C20)cycloalkenyl-(C═O)—O—, (C2-C20)alkynyl-(C═O)—O—, (C5-C25)aryl-(C═O)—O—, phenyl-(C═O)—O—, perhalo(C1-C20)alkyl-(C═O)—O—, and salts thereof;
• wherein each of the aforesaid (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (Chd 20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclic, (C2-C20)alkenyl, (C3-C20)cycloalkenyl, (C2-C20)alkynyl, (C5-C20)cycloalkynyl, and (C5-C25)aryl groups (for said R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 groups) may be optionally and independently substituted by one to four moieties selected from the group consisting of hydroxy, halo, bromo, chloro, iodo, fluoro, —N3, —CN, —NC, —SH, —NO2, —NH2, (C1-C20)alkyl, phenyl, (C3-C20)cycloalkyl, (C1-C20)alkoxy, (C3-C25)heteroaryl, (C3-C25)heterocyclic, (C2-C20)alkenyl, (C3-C20)cycloalkenyl, (C2-C20)alkynyl, (C5-C20)cycloalkynyl, (C5-C25)aryl, perhalo(C1-C20)alkyl, (C1-C20)alkyl-O—, phenyl-O—, (C3-C20)cycloalkyl-O—, (C3-C25)heteroaryl-O—, (C3-C25)heterocyclic-O—, (C2-C20)alkenyl-O—, (C3-C20)cycloalkenyl-O—, (C2-C20)alkynyl-O—, (C5-C20)cycloalkynyl-O—, (C5-C25)aryl-O—, perhalo(C1-C20)alkyl-O—, (C1-C20)alkyl-S—, phenyl-S—, (C3-C20)cycloalkyl-S—, (C3-C25)heteroaryl-S—, (C3-C25)heterocyclic-S—, (C2-C20)alkenyl-S—, (C3-C20)cycloalkenyl-S—, (C2-C20)alkynyl-S—, (C5-C20)cycloalkynyl-S—, (C5-C25)aryl-S—, perhalo(C1-C20)alkyl-S—, (C1-C20)alkyl-SO2—, phenyl-SO2—, (C3-C20)cycloalkyl-SO2—, (C1-C20)alkoxy-SO2—, (C3-C25)heteroaryl-SO2—, (C3-C25)heterocyclic-SO2—, (C2-C20)alkenyl-SO2—, (C3-C20)cycloalkenyl-SO2—, (C2-C20)alkynyl-SO2—, (C5-C20)cycloalkynyl-SO2—, (C5-C25)aryl-SO2—, perhalo(C1-C20)alkyl-SO2—, H2N—SO2—, (C1-C20)alkyl-NH—SO2—, phenyl-NH—SO2—, (C3-C20)cycloalkyl-NH—SO2—, (C1-C20)alkoxy-NH—SO2—, (C3-C25)heteroaryl-NH—SO2—, (C3-C25)heterocyclic-NH—SO2—, (C2-C20)alkenyl-NH—SO2—, (C3-C20)cycloalkenyl-NH—SO2—, (C2-C20)alkynyl-NH—SO2—, (C5-C20)cycloalkynyl-NH—SO2—, (C5-C25)aryl-NH—SO2—, perhalo(C1-C20)alkyl-NH—SO2—, {(C1-C20)alkyl}2N—SO2—, {phenyl}2N—SO2—, {(C3-C20)cycloalkyl}2N—SO2—, {(C1-C20)alkoxy}2N—SO2—, {(C3-C25)heteroaryl}2N—SO2—, {(C3-C25)heterocyclic}2N—SO2—, {(C2-C20)alkenyl}2N—SO2—, {(C2-C20)alkynyl}2N—SO2—, {(C5-C20)cycloalkynyl}2N—SO2—, {(C5-C25)aryl}2N—SO2—, {perhalo(C1-C20)alkyl}2N—SO2—, (C1-20)alkyl-SO2—NH—, phenyl-SO2—NH—, (C3-C20)cycloalkyl-SO2—NH—, (C1-C20)alkoxy-SO2—NH—, (C3-C25)heteroaryl-SO2—NH—, (C3-C25)heterocyclic-SO2—NH—, (C2-C20)alkenyl-SO2—NH—, (C3-C20)cycloalkenyl-SO2—NH—, (C2-C20)alkynyl-SO2—NH—, (C5-C20)cycloalkynyl-SO2—NH—, (C5-C25)aryl-SO2—NH—, perhalo(C1-C20)alkyl-SO2—NH—, (C1-C20)alkyl-NH—, phenyl-NH—, (C3-C20)cycloalkyl-NH—, (C1-C20)alkoxy-NH—, (C3-C25)heteroaryl-NH—, (C3-C25)heterocyclic-NH—, (C2-C20)alkenyl-NH—, (C3-C20)cycloalkenyl-NH—, (C2-C20)alkynyl-NH—, (C5-C20)cycloalkynyl-NH—, (C5-C25)aryl-NH—, perhalo(C1-C20)alkyl-NH—, {(C1-C20)alkyl}2N—, {phenyl}2N—, {(C3-C20)cycloalkyl}2N—, {(C1-C20)alkoxy}2N—, {(C3-C25)heteroaryl}2N—, {(C3-C25)heterocyclic}2N—, {(C2-C20)alkenyl}2N—, {(C3-C20)cycloalkenyl}2N—, {(C2-C20)alkynyl}2N—, {(C5-C20)cycloalkynyl}2N—, {(C5-C25)aryl}2N—, {perhalo(C1-C20)alkyl}2N—, (C1-C20)alkyl-(C═O)—NH—, phenyl-(C═O)—NH—, (C3-C20)cycloalkyl-(C═O)—NH—, (C1-C20)alkoxy-(C═O)—NH—, (C3-C25)heteroaryl-(C═O)—NH—, (C3-C25)heterocyclic-(C═O)—NH—, (C2-C20)alkenyl-(C═O)—NH—, (C3-C20)cycloalkenyl-(C═O)—NH—, (C2-C20)alkynyl-(C═O)—NH—, (C5-C20)cycloalkynyl-(C═O)—NH—, (C5-C25)aryl-(C═O)—NH—, perhalo(C1-C20)alkyl-(C═O)—NH—, (C1-C20)alkyl-C═O)—{((C1-C20)alkyl)N}—, phenyl-(C═O)—{((C1-C20)alkyl)N}—, (C3-C20)cycloalkyl-(C═O)—{((C1-C20)alkyl)N}—, (C1-C20)alkoxy-(C═O)—{((C1-C20)alkyl)N}—, (C3-C25)heteroaryl-(C═O)—{((C1-C20)alkyl)N}—, (C3-C25)heterocyclic-(C═O)—{((C1-C20)alkyl)N}—, (C2-C20)alkenyl-(C═O)—{((C1-C20)alkyl)N}—, (C3-C20)cycloalkenyl-(C═O)—{((C1-C20)alkyl)N}—, (C2-C20)alkynyl-(C═O)—{((C1-C20)alkyl)N}—, (C5-C20)cycloalkynyl-(C═O)—{((C1-C20)alkyl)N}—, (C5-C25)aryl-(C═O)—{((C1-C20)alkyl)N}—, perhalo(C1-C20)alkyl-(C═O)—{((C1-C20)alkyl)N}—, phenyl-(C═O)—NH—, phenyl-(C═O)-{(phenyl)N}—, (C1-C20)alkyl-(C═O)-{(phenyl)N}—, (C3-C20)cycloalkyl-(C═O)-{(phenyl)N}—, (C1-C20)alkoxy-(C═O)-{(phenyl)N}—, (C3-C25)heteroaryl-(C═O)-{(phenyl)N}—, (C3-C25)heterocyclic-(C═O)-{(phenyl)N}—, (C2-C20)alkenyl-(C═O)-{(phenyl)N}—, (C3-C20)cycloalkenyl-(C═O)-{(phenyl)N}—, (C2-C20)alkynyl-(C═O)-{(phenyl)N}—, (C5-C20)cycloalkynyl-(C═O)-{(phenyl)N}—, (C5-C25)aryl-(C═O)-{(phenyl)N}—, perhalo(C1-C20)alkyl-(C═O)-{(phenyl)N}—, H2N(C═O)—, (C1-C20)alkyl-NH—(C═O)—, phenyl-NH—(C═O)—, (C3-C20)cycloalkyl-NH—(C═O)—, (C1-C20)alkoxy-NH—(C═O)—, (C3-C25)heteroaryl-NH—(C═O)—, (C3-C25)heterocyclic-NH—(C═O)—, (C2-C20)alkenyl-NH—(C═O)—, (C3-C20)cycloalkenyl-NH—(C═O)—, (C2-C20)alkynyl-NH—(C═O)—, (C5-C20)cycloalkynyl-NH—(C═O)—, (C5-C25)aryl-NH—(C═O)—, perhalo(C1-C20)alkyl-NH—(C═O)—, {C1-C20)alkyl}2N—(C═O)—, {phenyl}{(C1-C20)alkyl}N—(C═O)—, {(C3-C20)cycloalkyl}{(C1-C20)alkyl}N—(C═O)—, {(C1-C20)alkoxy}{(C1-C20)alkyl}N—(C═O)—, {(C3-C25)heteroaryl}{(C1-C20)alkyl}N—(C═O)—, {(C3-C25)heterocyclic}{(C1-C20)alkyl}N—(C═O)—, {(C2-C20)alkenyl}{(C1-C20)alkyl}N—(C═O)—, {(C3-C20)cycloalkenyl}{(C1-C20)alkyl}N—(C═O)—, {(C2-C20)alkynyl}{(C1-C20)alkyl}N—(C═O)—, {(C5-C20)cycloalkynyl}{(C1-C20)alkyl}N—(C═O)—, {(C5-C25)aryl}{(C1-C20)alkyl}N—(C═O)—, {perhalo(C1-C20)alkyl}{(C1-C20)alkyl}N—(C═O)—, {phenyl}2N—(C═O)—, {(C3-C20)cycloalkyl}{phenyl}N—(C═O)—, {(C1-C20)alkoxy}{phenyl}N—(C═O)—,{(C3-C25)heteroaryl}{phenyl}N—(C═O)—, {(C3-C25)heterocyclic}{phenyl}N—(C═O)—, {(C2-C20)alkenyl}{phenyl}N—(C═O)—, {(C3-C20)cycloalkenyl}{phenyl}N—(C═O)—, {(C2-C20)alkynyl}{phenyl}N—(C═O)—, {(C5-C20)cycloalkynyl}{phenyl}N—(C═O)—, {(C5-C25)aryl}{phenyl}N—(C═O)—, {perhalo(C1-C20)alkyl}{phenyl}N—(C═O)—, HO—(C═O)—, (C1-C20)alkyl-(C═O)—, (C3-C25)heteroaryl-(C═O)—, (C3-C25)heterocyclic-(C═O)—, (C2-C20)alkenyl-(C═O)—, (C3-C20)cycloalkenyl-(C═O)—, (C2-C20)alkynyl-(C═O)—, (C5-C25)aryl-(C═O)—, perhalo(C1-C20)alkyl-(C═O)—, phenyl-(C═O)—, (C1-C20)alkyl-O—(C═O)—, (C3-C25)heteroaryl-O—(C═O)—, (C3-C25)heterocyclic-O—(C═O)—, (C2-C20)alkenyl-O—(C═O)—, (C3-C20)cycloalkenyl-O—(C═O)—, (C2-C20)alkynyl-O—(C═O)—, (C5-C25)aryl-O—(C═O)—, perhalo(C1-C20)alkyl-O—(C═O)—, phenyl-O—(C═O)—, (C1-C20)alkyl-(C═O)—O—, (C3-C25)heteroaryl-(C═O)—O—, (C3-C25)heterocyclic-(C═O)—O—, (C2-C20)alkenyl-(C═O)—O—, (C3-C20)cycloalkenyl-(C═O)—O—, (C2-C20)alkynyl-(C═O)—O—, (C5-C25)aryl-(C═O)—O—, phenyl-(C═O)—O—, perhalo(C1-C20)alkyl-(C═O)—O—, and salts thereof;
• and wherein two independently chosen R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 alkyl-containing groups may be taken together with any atom to which they are attached to form a three to forty membered cyclic, heterocyclic or heteroaryl ring.