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US 2006/0040992 A1Published application
Antiinflammatory 3-arylthio-3-thiazolyl-alkylamines
AssigneeAstraZeneca AB
InventorJeffrey Stonehouse
Life of this patent
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Abstract
There are provided novel compounds of formula (I) wherein T, X, Y and W are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
Claims18
A compound of formula (I)
- wherein:
- T and W independently represent CR1 or N;
- and when more than one R1 group is present, each may be selected independently;
- X and R1 independently represent H, C1 to 4 alkyl, C1 to 4 alkoxy, halogen, CN, C≡CH, NO2, CHO, COCH3 or NHCHO;
- said alkyl or alkoxy group being optionally further substituted by one or more fluorine atoms;
- Y represents C1 to 4 alkyl, C1 to 4 alkoxy, halogen, CN, C≡CH, NO2, CHO, COCH3 or NHCHO;
- said alkyl or alkoxy group being optionally further substituted by one or more fluorine atoms;
- or a pharmaceutically acceptable salt thereof.
5 more elements
(canceled)
7-12. (canceled)
Dependencies are inferred from the claim text.