Therapeutic agent for treating respiratory diseases containing 4-hydroxypiperidine derivative as active ingredient

An agent for preventing and/or treating respiratory diseases, comprising, as an active ingredient, a compound represented by following Formula (I):

• wherein A represents a group represented by L-W (wherein L represents a bond or methylene group;
• and W represents oxygen atom, a group represented by SOn (wherein n denotes an integer of 0 to 2) or a group represented by —NR7— (wherein R7 represents hydrogen atom or a lower alkyl group));
• each of G1 and G2 independently represents (CH2)r (wherein r denotes an integer of 0 to 2), wherein G1 and G2 may further be bridged by a lower alkylene group when both of “r”s in G1 and G2 are 1;
• Y represents a lower alkylene group, or benzylidene group unsubstituted or substituted by R4;
• Z represents a bond or oxygen atom, wherein Y may form a 5- or 6-membered ring with carbon atoms on the benzene ring when Z represents a bond;
• R1 represents nitro group, a lower alkoxycarbonyl group, carbamoyl group unsubstituted or mono- or di-substituted by lower alkyl groups, unprotected or protected hydroxyl group, unprotected or protected carboxyl group, unprotected or protected N-hydroxycarbamoyl group, a lower alkyl group substituted by unprotected or protected hydroxyl group, a lower alkyl group substituted by unprotected or protected carboxyl group, or tetrazolyl group;
• each of R2 and R3 independently represents hydrogen atom, a halogen atom, a lower alkyl group unsubstituted or substituted by one or more halogen atoms, a lower alkoxy group unsubstituted or substituted by one or more halogen atoms, or nitro group;
• each of R4 and R5 independently represents hydrogen atom, a halogen atom, a lower alkyl group unsubstituted or substituted by one or more halogen atoms, a lower alkoxy group unsubstituted or substituted by one or more halogen atoms, cyano group, or a lower alkylsulfonyl group;
• and R6 represents hydrogen atom or a lower alkyl group, provided that it is excluded that R1 is nitro group or unprotected or protected hydroxyl group when W is a group represented by SOn (wherein n denotes an integer of 0 to 2), a pharmaceutically acceptable salt thereof or a solvate of them.