Substituted aryl-amine derivatives and methods of use

A compound defined by Formula II

• or a pharmaceutically acceptable derivative thereof,
• wherein R is selected from 7-isoquinolinyl, 2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, oxo-2,3-dihydrobenzofuranyl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6-quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-1,3-benzodioxol-5-yl and 2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substitutions selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl, morpholinyl, carboxyl, cyano, and acetyl;
• wherein R1 is selected from unsubstituted or substituted 1,2-dihydroquinolyl, 1,2,3,4-tetrahydroquinolyl, 1,2,3,4-tetrahydro-isoquinolyl, 2-oxo-1,2,3,4-tetrahydroquinolyl, 2-oxo-1,2,3,4-tetrahydroquinolyl, 1-oxo-1,2,3,4-tetrahydro-isoquinolyl, isoquinolyl, quinolyl, indol-6-yl, 6-isoindolyl, 3,4-dihydro-2H-benzo[1,4]oxazin-6-yl, 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl, 2,3-dihydro-1H-indol-6-yl, naphthyridinyl, 2-oxo-3,4-dihydro-1H-[1,8]naphthyridin-7-yl, 3,4-dihydro-[1,8]naphthyridinyl, 1,2,3,4-tetrahydro-[1,8]naphthyridinyl, quinozalinyl,
• wherein substituted R1 is substituted with one or more substituents selected from halo, optionally substituted C1-6-alkyl, optionally substituted C3-6-cycloalkyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4-alkylenyl, C1-2-haloalkoxy, optionally substituted phenyloxy, optionally substituted 4-6 membered heterocyclyl-C1-C6-alkyl, optionally substituted 4-6 membered heterocyclyl-C2-C4-alkenyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyloxy, optionally substituted 4-6 membered heterocyclyl-C1-4-alkoxy, optionally substituted 4-6 membered heterocyclylsulfonyl, optionally substituted 4-6 membered heterocyclylamino, optionally substituted 4-6 membered heterocyclylcarbonyl, optionally substituted 4-6 membered heterocyclyl-C1-4-alkylcarbonyl, optionally substituted 4-6 membered heterocyclylcarbonyl-C1-4-alkyl, optionally substituted 4-6 membered heterocyclyl-C1-4-alkylcarbonylamino, optionally substituted 4-6 membered heterocyclyl-oxycarbonylamino, C1-2-haloalkyl, C1-4-aminoalkyl, optionally substituted C1-4-aminoalkylcarbonyl, nitro, amino, C1-3-alkylsulfonylamino, hydroxy, cyano, aminosulfonyl, C1-2-alkylsulfonyl, C1-2-alkylsulfonylamino, C1-2-alkylsulfonylamino-C1-4-alkoxy, halosulfonyl, C1-4-alkylcarbonyl, amino-C1-4-alkylcarbonyl, C1-3-alkylamino-C1-4-alkylcarbonyl, C1-3-alkylamino-C1-4-alkylcarbonylamino, C1-4-alkoxycarbonyl-C1-4-alkyl, C1-3-alkylamino-C1-3-alkyl, C1-3-alkylamino-C1-3-alkoxy, C1-3-alkylamino-C1-3-alkoxy-C1-3-alkoxy, C1-4-alkoxycarbonyl, C1-4-alkoxycarbonylamino-C1-4-alkyl, C1-3-alkylsulfonylamino-C1-3-alkoxy, C1-4-hydroxyalkyl,
• and C1-4-alkoxy;
• and
• wherein Re and Rf are independently selected from H and C1-2-haloalkyl;
• wherein R7 is selected from H, C1-3-alkyl, optionally substituted phenyl, optionally substituted phenyl-C1-3-alkyl, 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-C1-C3-alkyl, C1-3-alkoxy-C1-2-alkyl and C1-3-alkoxy-C1-3-alkoxy-C1-3-alkyl;
• and
• wherein R2 is selected from H, halo, haloalkyl and C1-6 alkyl.