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US 2006/0040942 A1Published application
5-ethylimidarotriazones
AssigneeBayer HealthCare LLC
InventorsCristina Alonso-Alija, Heike Gielen-Haertwig, Martin Michels, Dagmar Karthaus, Hilmar Bischoff, Nils Burkhardt, Volker Geiss, Karl-Heinz Schlemmer, Nigel Cuthbert, Mary Fitzgerald, Graham Sturton, Ulrich Niewohner, Maria Niewohner
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Abstract
The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
Claims12
A compound of the general formula (I)
- in which
- A denotes phenylene or pyridinylene, which can be substituted by 0 to 3 residues selected independently from the group consisting of halogen, (C1-C4)-alkyl, trifluoromethyl, cyano, nitro, (C1-C4)-alkoxy and trifluoromethoxy,
- R1 denotes hydroxy or a group of the formula —NR3R4, —X—C(═O)—OR5 or —X—C(═O)—NR6R7, wherein
- X denotes a bond, —CH2—, —CH2—CH2— or —CH═CH—,
- R3 and R4 are independently selected from the group consisting of hydrogen, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C1-C6)-alkanoyl and (C6-C10)-aroyl, wherein (C1-C6)-alkyl can be further substituted with 0 to 3 substituents selected independently from the group consisting of (C3-C7)-cycloalkyl and (C6-C10)-aryl,
- R5 denotes hydrogen or (C1-C6)-alkyl,
- R6 and R7 are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C3-C7)-cycloalkyl and (C6-C10)-aryl, or together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocyclic ring which may contain one additional ring heteroatom selected from N, O or S,
- R2 denotes (C3-C10)-cycloalkyl, which is optionally substituted up to two times by residues selected independently from the group consisting of (C1-C6)-alkyl, (C1-C6)-alkoxy, hydroxy, halogen, trifluoromethyl and oxo.
5 more elements
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.