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US 2006/0040941 A1Published application
7-Aminoimidazotriazones
AssigneeBayer HealthCare LLC
InventorsCristina Alonso-Alija, Heike Gielen-Haertwig, Martin Michels, Dagmar Karthaus, Hilmar Bischoff, Nils Burkhardt, Volker Geiss, Karl-Heinz Schlemmer, Nigel Cuthbert, Mary Fitzgerald, Graham Sturton, Ulrich Niewohner, Maria Niewohner
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Abstract
The invention relates to novel 7-amino-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
Claims11
Compounds of the general formula (I)
- in which
- R1 denotes phenyl or 5- to 6-membered heteroaryl, which can be substituted by 0, 1, 2 or 3 residues independently selected from the group consisting of halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, trifluoromethyl, cyano, nitro and trifluoromethoxy,
- R2 denotes hydrogen, (C1-C8)-alkyl or (C3-C8)-cycloalkyl, and
- R3 denotes (C1-C8)-alkyl or (C3-C8)-cycloalkyl, or
- NR2R3 denotes optionally benzannelated, 4- to 10-membered heterocyclyl,
- which contains at least one nitrogen ring atom,
- which is attached to the imidazotriazinone by a nitrogen ring atom, and
- which can be substituted by 0, 1, 2 or 3 residues independently selected from the group consisting of halogen, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkoxycarbonyl, hydroxy, halogen, trifluoromethyl and oxo.
5 more elements
Dependencies are inferred from the claim text.