Benzamide inhibitors of the P2X, receptor

A compound of the formula

• wherein R1 is (C1-C6)alkyl, optionally substituted by (C3-C10)cycloalkyl, (C6-C10)aryl, (C1-C10)heterocyclyl, or (C1-C10)heteroaryl, wherein each of said (C1-C6)alkyl, (C3-C10)cycloalkyl, (C6-C10)aryl, (C1-C10)heterocyclyl, or (C1-C10)heteroaryl are optionally substituted by one to three suitable moieties independently selected from the group consisting of hydroxy, halogen, CN—, (C1-C6)alkyl, HO(C1-C6)alkyl, (C1-C6)alkyl-NH(C═O)—, NH2(C═O)—, (C1-C6)alkoxy, or (C3-C10)cycloalkyl, wherein said (C3-C10)cycloalkyl is optionally substituted by one or more moieties selected from halogen, or (C1-C6)alkyl-;
• R2 is hydrogen, halogen, —CN, and (C1-C6)alkyl, wherein said (C1-C6)alkyl is optionally substituted by one to three suitable moieties, independently selected from the group consisting of halo, hydroxy, amino, —CN, (C1-C6)alkyl, (C1-C6)alkoxy, —CF3, CF3O—, (C1-C6)alkyl-NH—, [(C1-C6)alkyl]2—N—, (C1-C6)alkyl-S—, (C1-C6)alkyl-(S═O)—, (C1-C6)alkyl-(SO2)—, (C1-C6)alkyl-O—(C═O)—, formyl, (C1-C6)alkyl-(C═O)—, and (C3-C6)cycloalkyl;
• R3 is a nitrogen linked (C1-C10)heterocyclyl of the formula:
• wherein R4 is independently selected from the group of suitable substituents, such as hydrogen, halo, hydroxy, —CN, HO—(C1-C6)alkyl, (C1-C6)alkyl optionally substituted with one to three fluoro, (C1-C6)alkoxy optionally substituted with one to three fluoro, HO2C—, (C1-C6)alkyl-O—(C═O)—, R5R6N(O2S)—, (C1-C6)alkyl-(O2S)—NH—, (C1-C6)alkyl-O2S—[(C1-C6)alkyl-N]—, R5R6N(C═O)—, R5R6N(CH2)m—, (C6-C10)aryl, (C3-C8)cycloalkyl, (C1-C10)heteroaryl, (C1-C10)heterocyclyl, (C6-C10)aryl-O—, (C3-C8)cycloalkyl-O—, (C1-C10)heteroaryl-O— and (C1-C10)heterocyclyl-O—;
• and
• R7 is independently selected from the group of suitable substituents such as hydrogen and (C1-C6)alkyl optionally substituted with one to three halogens, hydroxy, —CN, (C1-C6)alkoxy-, (C2-C6)alkenoxy, (C1-C6)alkyl-SO2—, NH2—, ((C1-C6)alkyl), —N—, ((C2-C6)alkenyl), —N—, ((C2-C6)alkynyl), —N—, NH2(C═O)—, (C1-C6)alkyl-(C═O)N—, ((C1-C6)alkyl), —N—(C═O)—, (C2-C6)alkenyl-(C═O)N—, ((C2-C6)alkenyl), —N—(C═O)—, (C2-C6)alkynyl-(C═O)N—, ((C2-C6)alkynyl)n—N—(C═O)—, (C1-C6)alkyl-(C═O)—, (C2-C6)alkenyl-(C═O)—, (C2-C6)alkynyl-(C═O)—, (C3-C10)cycloalkyl-(C═O)—, ((C1-C10)heterocyclyl-(C═O)—, (C6-C10)aryl-(C═O), (C1-C10)heteroaryl-(C═O), (C1-C6)alkyl-(C═O)O—, (C2-C6)alkenyl-(C═O)O—, (C2-C6)alkynyl-(C═O)O—, (C1-C6)alkyl-O(C═O)—, (C2-C6)alkenyl-O—(C═O)—, (C2-C6)alkynyl-O—(C═O)—, (C3-C10)cycloalkyl, (C6-C10)aryl, (C1-C10)heterocyclyl, and (C1-C10)heteroaryl;
• wherein R4 and R7 may each be optionally substituted on any aliphatic or aromatic carbon atom by one to three suitable moieties, independently selected from the group consisting of halo, hydroxy, amino, —CN, (C1-C6)alkyl, (C1-C6)alkoxy, —CF3, CF3O—, (C1-C6)alkyl-NH—, [(C1-C6)alkyl]2—N—, (C1-C6)alkyl-S—, (C1-C6)alkyl-(S═O)—, (C1-C6)alkyl-(SO2)—, (C1-C6)alkyl-O—(C═O)—, formyl, (C1-C6)alkyl-(C═O)—, and (C3-C6)cycloalkyl;
• R5 and R6 are each independently selected from the group consisting of hydrogen, (C1-C6)alkyl, HO—(C2-C6)alkyl and (C3-C8)cycloalkyl, or R5 and R6 may optionally be taken together with the nitrogen atom to which they are attached to form a 3 to 8 membered heterocycle;
• n is an integer from zero to two;
• and
• m is an integer from one to two;
• or the pharmaceutically acceptable salts or solvates thereof.