Nonsteroidal antiinflammatory agents

A compound of formula I

• wherein
• R1 and R2 are the same or different and stand for a hydrogen atom, a C1-C5 alkyl group, or, together with the C-atom of the chain, stand for a ring with a total of 3-7 links;
• R3 is a straight-chain or branched C1-C5 alkyl group or a straight-chain or branched, partially or completely fluorinated C1-C5 alkyl group;
• A stands for the group
• wherein the dashed line means the interface site;
• R4 is methyl, nitro, amino, acetylamino, or mesylamino;
• R5, R6, and R8 are the same or different from one another and are each a hydrogen atom, a halogen atom, a cyano group, a nitro group, a COOR9 group, a CONR10 group, or an NHR11 group, a straight-chain or branched C1-C5 alkyl group, a straight-chain or branched C2-C5 alkenyl group, a straight-chain or branched C2-C5 alkinyl group, a straight-chain or branched C1-C5 alkyl group that is partially or completely substituted by fluorine atoms, a C1-C5 acyl group, an aryl radical or a heteroaryl radical;
• R7 is halogen;
• R9 is a hydrogen atom, a straight-chain or branched C1-C5 alkyl group or a benzyl group;
• R10 is a hydrogen atom or a straight-chain or branched C1-C5 alkyl group;
• R11 is a hydrogen atom, a straight-chain or branched C1-C5 alkyl group, a straight-chain or branched, partially or completely fluorinated C1-C5 alkyl group, a C1-C5 acyl group, an —SO2—(C1-C5) alkyl group or an —SO2-phenyl group that is optionally substituted by halogen or a C1-C5 alkyl group;
• Ar is the ring system
• X3a and X3b are the same or different and are each a hydrogen atom, a straight-chain or branched C1-C5 alkyl group, or a straight-chain or branched, partially or completely fluorinated C1-C5 alkyl group;
• and
• X4, X6, and X7 are the same or different and are each a hydrogen atom, a straight-chain or branched C1-C5 alkyl group, a straight-chain or branched, partially or completely fluorinated C1-C5 alkyl group, a halogen atom, a hydroxy group, a C1-C5 alkoxy group or a C1-C5 alkanoyloxy group;
• and
• physiologically compatible salts thereof, wherein said compound can also be in the form of a racemate or in the form of separate stereoisomers.

A compound selected from the following compounds:

• 5-[4-(5-fluoro-2-methylphenyl)-2-hydroxy-4-methyl-2-trifluoromethylvaleroylamino]-phthalide;
• 5-[4-(5-fluoro-2-nitrophenyl)-2-hydroxy-4-methyl-2-trifluoromethylvaleroylamino]-phthalide;
• 5-[4-(3-fluoro-4-nitrophenyl)-2-hydroxy-4-methyl-2-trifluoromethylvaleroylamino]-phthalide;
• 5-[4-(2-amino-5-fluorophenyl)-2-hydroxy-4-methyl-2-trifluoromethylvaleroyl-amino]-phthalide;
• (−) 5-[4-(2-amino-5-fluorophenyl)-2-hydroxy-4-methyl-2-trifluoromethylvaleroyl-amino]-phthalide;
• (+) 5-[4-(2-amino-5-fluorophenyl)-2-hydroxy-4-methyl-2-trifluoromethylvaleroyl-amino]-phthalide;
• 5-[4-(2-acetylamino-5-fluorophenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide;
• (−) 5-[4-(2-acetylamino-5-fluorophenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide;
• (+) 5-[4-(2-acetylamino-5-fluorophenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide;
• 5-[4-(5-fluoro-2-mesylaminophenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide;
• (−) 5-[4-(5-fluoro-2-mesylaminophenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide;
• (+) 5-[4-(5-fluoro-2-mesylaminophenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide;
• and
• physiologically compatible salts thereof.