Novel substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same

Compounds of formula (I):

• wherein:
• A, together with the carbon atoms to which it is bonded, represents a group of formula (a) or (b):
• wherein:
• W1, together with the carbon atoms to which it is bonded, represents a phenyl group or a pyridyl group,
• Z represents a group selected from hydrogen and halogen atoms and the groups linear or branched (C1-C6)alkyl, nitro, cyano, hydroxy, linear or branched (C1-C6)alkoxy, aryl, aryl-(C1-C6)alkyl (in which the alkyl moiety is linear or branched), aryloxy and aryl-(C1-C6)alkoxy (in which the alkoxy moiety is linear or branched) and NR5R6 wherein R5 and R6, which are identical or different, each independently of the other represents a group selected from a hydrogen atom and a linear or branched (C1-C6)alkyl group,
• R4 represents a group selected from a hydrogen atom and the groups linear or branched (C1-C6)alkyl, aryl and aryl-(C1-C6)alkyl (in which the alkyl moiety is linear or branched) or a group —C(O)—OR′5 wherein R′5 represents a group selected from the groups linear or branched (C1-C6)alkyl, aryl and aryl-(C1-C6)alkyl (in which the alkyl moiety is linear or branched),
• Y represents a group selected from an oxygen atom and a methylene group,
• R2 represents a hydrogen atom and, in that case:
• R3 represents a group selected from a hydrogen atom and the groups linear or branched (C1-C6)alkyl, aryl, aryl-(C1-C6)alkyl (in which the alkyl moiety is linear or branched) and SO2CF3,
• or R2 and R3 form a bond,
• R1 represents a group selected from a hydrogen atom and the groups linear or branched (C1-C6)alkyl, aryl and aryl-(C1-C6)alkyl (in which the alkyl moiety is linear or branched) or a linear or branched (C1-C6)alkylene chain substituted by one or more identical or different groups selected from —OR″5 and —NR″5R″6 wherein R″5 and R″6 are as defined for R5 and R6 defined hereinbefore,
• Z1 and Z2 each represent a hydrogen atom or
• Z1 and Z2, together with the carbon atoms carrying them, form a phenyl group,
• with the proviso that, when Z represents a hydrogen atom, R1 is other than a hydrogen atom,
• their enantiomers, diastereoisomers, N-oxide, and addition salts thereof with a pharmaceutically acceptable acid or base,
• wherein “aryl” is to be understood as meaning a phenyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, indenyl or indanyl group, each of those groups being optionally substituted by one or more identical or different groups selected from halogen, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)trihaloalkyl, hydroxy, linear or branched (C1-C6)alkoxy, and amino optionally substituted by one or two linear or branched (C1-C6)alkyl groups.